David Zhen , MD

Email: dbzhen@uw.edu

Phone: (206) 606-1733

Dr. Zhen is a medical oncologist who specializes in treating patients with gastrointestinal cancers.

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Ning Zheng , PhD

Email: nzheng@u.washington.edu

Phone: (206) 616-3990

The research in Dr. Ning Zheng's lab focuses on a superfamily of multi-component protein complexes, known as cullin-RING ubiquitin ligases as well as the emerging family of ubiquitin-specific proteases. By controlling protein turnover, these cellular machines regulate diverse biological processes, such as cell cycle progression, signal transduction, transcription, DNA repair, and metabolism. Dysregulation of these complexes has been associated with multiple human disorders including cancer, neurological disease, and viral infection. He utilizes protein complex X-ray crystallography in his research to determine the atomic 3-D structures of the protein machines they are interested in and identify novel therapeutic targets for developing anti-cancer treatments.

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Ying Zheng , PhD

Email: yingzy@uw.edu

Phone: (206) 543-3223

Dr. Zheng's research focuses on understanding and engineering the fundamental structure and functions in living tissue and organ systems from nanometer, micrometer to centimeter scale. Our research integrates the knowledge of biology and medicine, transport phenomena, matrix mechanics, and microfluidic technologies. With this means, we aim to recreate 3D physiological microenvironment in vitro, rebuild organ functional units for developmental biology, and ultimately engineer vascularized tissue and organs.

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Yingye Zheng , PhD

Email: yzheng@fredhutch.org

Phone: (206) 667-7580

Dr. Zheng's research interests have been in the statistical methods for longitudinal data with time-to-event outcome, with a focus on using semi-parametric methods for estimating time-dependent ROC curves which are useful for evaluating the ability of longitudinal biomarkers or algorithms to identify cancer early, or signal disease prognosis. Her work is also focused on statistical methods for family-based genetic association studies. She is presently providing support to a number of research proposals and applications in the cancer prevention research program, including serving as an investigator in the DMCC of the Early Detection Research Network.

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Steven Ziegler , PhD

Email: sziegler@benaroyaresearch.org

Phone: (206) 287-5657

The projects in Dr. Ziegler’s laboratory are focused on the factors that control normal immune regulation, as well as those that contribute to disease development and progression. The laboratory is currently engaged in two areas of investigation: the genes and cell populations that are involved in controlling autoimmune-type responses, and the role of epithelial cytokines (TSLP, IL-25, and IL-33) in the regulation of barrier responses to infection and allergen challenge. Finally, they have also found a novel role for TSLP in the regulation of tumor progression, and have established a program in tumor biology, including metastatic breast cancer, colitis-associated cancer and melanoma.

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