Jesse Bloom , PhD

Email: jbloom@fredhutch.org

Phone: (206) 667-3622

Dr. Bloom studies the molecular evolution of proteins and viruses. Rapid evolution is a defining feature of many of the most medically problematic viral diseases, including influenza. Although this rapid evolution is usually bad from the perspective of public health, it offers a unique vantage from which to study a range of important questions in biology. His group takes an evolutionary perspective as we use a combination of experimental and computational techniques to study questions in virology, immunology, and protein biochemistry.

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Karl Bohringer , PhD

Email: karlb@u.washington.edu

Phone: (206) 221-5177

Dr. Bohringer's current research interests include micromanipulation and microassembly, as well as biomedical implants and bioMEMS for single-cell genomics and proteomics. There are two major research themes in his work: Controlling surfaces and interfacial forces at the micro and nano scale, including systems for controlled self-assembly of microcomponents, programmable surfaces whose local properties (for example, hydrophobicity) can be changed on demand, and MEMS actuator arrays and microrobots for moving tiny objects; Joining MEMS and biology by integrating new biomaterials into MEMS processes and devices, biomedical sensor implants, and microfluidic chips for handling and analyzing biological samples. Dr. Bohringer is also interested in discussing ideas for leveraging the unique capabilities of the Washington Nanofabrication Facility for research programs in the biomedical field.

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Hamid Bolouri , PhD

Email: hbolouri@fredhutch.org

Phone: (206) 667-2748

Dr. Bolouri is interested in understanding how gene regulatory interactions control cellular state and identity, both in normal development and in diseases such as cancer. A particular focus of his lab is the development and use of integrative computational systems biology methods to map gene regulatory networks from whole genome data: currently they are working on identification of cis-regulatory sequence variations in childhood Acute Myeloid Leukemia.

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Karol Bomsztyk , MD

Email: karolb@uw.edu

Phone: (206) 616-7949

Dr. Bomstyzk areas of research interest include pathogenesis of bacterial, fungal and parasitic diseases; epigenetics of inflammation and infection; and epigenetics of HIV infection.

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Lynn Bonham , PhD

Email: lbonham@seattlecca.org

Phone: (206)288-2022

Dr. Bonham directs and manages Cellular Therapeutics at SCCA, which processes cells from peripheral blood, bone marrow and cord blood for standard transplantations and clinical trials for cancer treatment.

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Mark Bothwell , PhD

Email: mab@uw.edu

Phone: (206) 543-7924

Dr. Bothwell's research interest is the regulatory function of growth factors in the developing nervous system during embryonic development. Moreover, he is interested in the functions of growth factors in the adult nervous system, in the processes of memory and learning, in the repair of nervous system injury, in neurodegenerative conditions and also their role in tumor biology.

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Denise Boudreau , PhD, MS

Email: boudreau.d@ghc.org

Phone: (206) 287-2067

Dr. Boudreau's area of expertise is Pharmacoepidemiology. Her research ranges from cancer to cardiovascular disease. Her latest project explores the influence of commonly used medications such as statins and chronic antibiotic use on breast cancer outcomes. Dr. Boudreau is also an expert at pharmaco-economic studies such as reviewing the costs and effects of using medications on biologic and screening endpoints for breast cancer and cost of false positive mammography.

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Stephen Bowen , PhD

Email: srbowen@uw.edu

Phone: (206) 598-1128

Dr. Bowen's research focuses on quantitative molecular imaging of cancer and normal tissue for personalized radiation therapy. Specifically he is interested in machine learning of respiratory patterns for personalized motion management strategies during image acquisition, radiotherapy planning, and radiotherapy delivery; dose painting based on respiratory-gated FDG PET in NSCLC; and functional avoidance planning of both MAA and DTPA SPECT-defined lung regions in NSCLC and SC SPECT-defined liver regions in HCC.

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Ivana Bozic , PhD

Email: ibozic@uw.edu

Phone: (206) 543-5077

Dr. Bozic studies the evolution of cancer and its resistance to treatment through mathematical and computational modeling. Her interests lie in both theoretical aspects of these models and their application. On the theoretical side, Bozic studies stochastic processes, especially multi-type branching processes, and their finite time characteristics. Dr. Bozic collaborates extensively with experimental and clinical researchers to integrate modeling with clinical data, providing insight into the natural history of cancer in vivo.

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Phil Bradley , PhD

Email: pbradley@fredhutch.org

Phone: (206) 667-7041

Dr. Bradley's research is focused on developing predictive models of molecular recognition using high-resolution structural modeling. His group is currently working to predict the specificity of protein-DNA and protein-peptide interactions. They develop and apply new algorithms for molecular modeling within the framework of the Rosetta software package, a set of tools for the prediction and design of protein structures and interactions.

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Robert Bradley , PhD

Email: rbradley@fredhutch.org

Phone: (206) 667-5662

Dr. Bradley uses genomics, sequence analysis, and molecular genetics to study the mechanistic origins and phenotypic consequences of alternative splicing and other RNA processing. He wants to identify diseases where RNA processing plays important, and previously unrecognized, roles. His laboratory studies pre-neoplastic diseases and cancers such as brain, prostrate and breast cancer.

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Debbie Bradshaw , MSc, DPhil

Email: debbie.bradshaw@mrc.ac.za

Phone: +27 21 9380944 

Professor Bradshaw trained as a biostatistician and has expertise in epidemiology and demography. Her main research interests are non-communicable disease mortality, maternal mortality, diabetes-related mortality, and changes in population health in regards to obesity and tobacco use.

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Linda Breeden , PhD

Email: lbreeden@fredhutch.org

Phone: (206) 667-4484

Dr. Breeden's research is focused on understanding how the commitment to the mitotic cell cycle is regulated in response to environmental and internal cues. The critical transitions in the eukaryotic cell cycle are controlled by cyclin-dependent kinases (CDKs). In budding yeast, as in all higher eukaryotes, the decision to commit to another division cycle occurs in G1. Nine cyclins have been identified that bind and activate a single CDK, and three of these cyclins (Cln1,2 and 3) play critical roles in modulating the decision to enter the cell cycle. Her lab's long term goal has been to understand how the commitment to the mitotic cell cycle is regulated in response to environmental and internal cues. Most of this work has been done with rapidly growing cells and with cells subjected to DNA damage.

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William Bremner , MD, PhD

Email: wbremner@u.washington.edu

Phone: (206) 543-3293

Dr. Bremner is an endocrinologist with expertise in the effects of testosterone and other androgens, especially in aging men. Dr. Bremner researches the effects of androgens and their metabolites on the body and the development of male contraceptives.

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Roger Brent , PhD

Email: rbrent@fredhutch.org

Phone: (206) 667-1482

Dr. Brent studies the quantitative operation of the systems that living cells use to sense, represent, transmit, and act upon information to make decisions that determine their future fates. He specifically studies prototypic cell signaling systems in budding yeast and the pheromone response system; he has extended similar work to systems operating in single cells of tissues in a metazoan, Caenorhabditis elegans.

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Teresa Brentnall , MD

Email: teribr@u.washington.edu

Phone: (206) 897-1821

Dr. Brentnall research interest is in understanding tumorigenesis in the gastrointestinal tract with emphasis in: molecular events and early detection of pancreatic cancer; surveillance and management of patients who inherit pancreatic cancer; molecular events, prevention, and early detection of colon cancer in patients with inflammatory bowel disease.

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David Brieger , PhD

Email: breiger@u.washington.edu

Phone: (206) 987-2164

Dr. Breiger is interested in neuropsychological outcomes of children with brain tumors, neuropsychological and psychosocial adjustment of long-term survivors of acute lymphocytic leukemia, neuropsychological functioning in children with thought disorders or chronic fatigue syndrome and the cultural context and understanding of autism.

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James (Jim) Brinkley , MD, PhD

Email: brinkley@u.washington.edu

Phone: (206) 543-3954

Dr. Brinkley's primary research interest is biomedical informatics - the representation, management, sharing, visualization and utilization of neuroscience data and knowledge. He is the founder of the field of Structural Informatics, which has as its goal the development of methods for representing the structure of the body at multiple levels of detail, as for using these methods for organizing and integrating biomedical information. His aim is to find ways to represent the structure or the body in computer-readable form, and find ways to associate these representations with the myriad biomedical data that are available. His goal is to provide a structural information framework for integrating a huge variety of big and small biomedical data. Dr. Brinkley's projects have included anatomy education, brain mapping through the national Human Brain Project, cardiovascular data integration, clinical trials data integration through the national Clinical translational Science Awards, radiological image annotation and integration through the RadLex project, and craniofacial malformations data integration through the national FaceBase consortium. He is also interested in developing web-accessible computer applications utilizing these representations to solve practical problems in clinical medicine, research and education.

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Samuel Robert Browd , MD, PhD

Email: sbrowd@u.washington.edu

Phone: (206) 987-4240

Dr. Browd's specialties are with children who have hydrocephalus, brain & spinal cord tumors, pediatric cervical spine, spina bifida, chiari malformations, spasticity. His research interests include complex, high resolution medical imaging including Functional Neuro Imaging; clinical trials and patient outcome; craniopagus twins; cervical spine issues related to down syndrome.

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Brian Browning , PhD

Email: browning@uw.edu

Phone: (206) 685-8482

Dr. Browning's research is focused on the development of statistical and computational methods for analysis of large-scale genetic data from microarray genotyping and next-generation sequencing. These genetic data sets present computational and analytical challenges due to their size, and due to the complex patterns of inter-marker correlation in the data. Carefully engineered algorithms and software are necessary to extract the full information from these rich data sets.

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