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Cole DeForest , PhD

Email: ProfCole@uw.edu

Phone: (206) 543-5961

The DeForest Group seeks to integrate the governing principles of rational design with fundamental concepts from material science, synthetic chemistry, and stem cell biology to conceptualize, create, and exploit next-generation materials to address a variety of health-related problems. They are currently interested in the development of new classes of user-programmable hydrogels whose biochemical and biophysical properties can be tuned in time and space over a variety of scales. Their work relies heavily on the utilization of cytocompatible bioorthogonal chemistries, several of which can be initiated with light and thereby confined to specific sub-volumes of a sample. By recapitulating the dynamic nature of the native tissue through 4D control of the material properties, these synthetic environments are utilized to probe and better understand basic cell function as well as to engineer complex heterogeneous tissue.

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Neelendu (Neel) Dey , MD

Email: ndey@fredhutch.org

Phone: (206) 667-6649

Dr. Dey studies how the gut microbiome influences health and disease. His lab is characterizing how the gut microbiota interface with the host to regulate physiology (e.g. gut motility) and pathophysiology (e.g. colorectal cancer), with an initial focus on how bile acids (and differential bacterial bile acid metabolism) mediate these effects.

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Manjiri Dighe , MD, FSAR, FSRU

Email: dighe@uw.edu

Phone: 206-598-0024

Dr. Dighe is section chief of body imaging at the University of Washington and a UW associate professor of radiology. In addition to body imaging, she is an expert in obstetric and thyroid imaging. She also conducts research on thyroid nodules using non-invasive ways to diagnose malignancy which includes ultrasound elastography. She also has a long interest and expertise in obstetric imaging and works closely with the Maternal Fetal Medicine group in UW to diagnose complex cases.

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Jason Dominitz , MD, MHS

Email: dominitz@u.washington.edu

Phone: (206) 764-2285

Dr. Dominitz is a gastroenterologist whose clinical expertise is colorectal cancer screening; colonoscopy and polyp removal. His research interests include outcomes research in gastroenterology with specific interest in the epidemiology of gastrointestinal and liver disease.

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Marianne Dubard-Gault , MD, MS

Email: mdg2019@uw.edu

Dr. Dubard-Gault is the medical director of the Cancer Genetics Program at SCCA. Her main research interest is to better understand how genetic information influences patients’ decision-making about health care and life choices. She is also interested in exploring ways to help people better access medical genetic information, talk about it with their families and use that knowledge to make decisions that fit their goals.

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Robert Eisenman , PhD

Email: eisenman@fredhutch.org

Phone: (206) 667-4445

Dr. Eisenman studies how cell proliferation, growth, and differentiation are regulated through the actions of transcriptional networks, and how this regulation is subverted during tumor progression. Specifically, his laboratory research focuses on gaining a deeper understanding of the mechanisms of an oncogenic transcription factor network (Myc/Max/Mxd) which is fundamental in all cancers.

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William Grady , MD

Email: wgrady@fredhutch.org

Phone: (206) 667-1107

Dr. Grady is an expert in the treatment of colorectal cancer, esophageal cancer, gastric cancer, and stomach cancer. He believes prevention and early detection are key to effective management of cancer. His research interests are in molecular and cell biology of gastrointestinal cancer: genetic and epigenetic alterations in cancer; biomarkers for colon cancer prevention, and biomarkers for optimizing management of Barretts esophagus. He also has experience in clinical management of gastrointestinal cancer family syndromes.

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Jonathan Grim , MD, PhD

Email: jgrim@fredhutch.org

Phone: (206) 667-7994

Dr. Grim is an oncologist who specializes in Medical Oncology and Hematology & Oncology.

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Barry Gumbiner , PhD

Email: gumbiner@uw.edu

Phone: 206-884-5116

Dr. Gumbiner and his team study how cadherin cell adhesion molecules and associated catenin proteins control tumor development and progression. Cadherins and catenins play important roles in the morphogenesis, maintenance, and regeneration of tissues, and alterations in their functions are important in cancer. One major effort of the laboratory is to understand how cadherins signal into the cell to control growth and differentiation through regulation of both the Wnt-beta-catenin pathway and the Hippo signaling pathway; the latter inhibits cell proliferation and participates in organ size control. Cadherins mediate contact inhibition of growth by stimulating the Hippo pathway, while growth factors, such as EGF, inhibit the Hippo pathway. They are investigating how these modes of regulation of the Hippo pathway affect the development of different types of tumors. Another major effort of the laboratory is to understand how cadherin adhesive function at the cell surface is regulated to control tissue architecture and tumor cell invasion. Loss of E-cadherin expression associated with the epithelial-mesenchymal transition (EMT) is known to promote tumorigenesis and metastasis. However, many tumors and metastases retain E-cadherin expression, and they have found that instead it can be inactivated at the cell surface to cause the loss in function. They have generated a novel class of monoclonal antibodies that activate E-cadherin at the cell surface to restore its adhesive function, and are evaluating whether they reduce tumor invasion and metastasis in animal models. He and his team are also studying how catenins and cancer-associated mutations in E-cadherin affect its ability to switch to the active state and regulate tumor development. The mechanisms by which cadherins and catenins affect tumor growth are varied and complex and offer potential approaches for intervention.

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William Harris , MD

Email: wph3@u.washington.edu

Phone: (206) 288-6856

Dr. William Harris specializes in caring for people with hepatobiliary, pancreatic, and gastrointestinal malignancies including pancreas, colon, rectal, anal, gastric, esophageal, and neuroendocrine tumors. His research interests include, hepatocellular carcinoma, cholangiocarcinoma and clinical trials combining chemotherapy and biologic therapies.

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Chad (Qianchuan) He , PhD

Email: qhe@fredhutch.org

Phone: (206) 667-7068

Dr. He's research is focused on the development of new statistical methods to tackle the high-dimensionality of genomic data, with the aim to achieve sparse models, consistent estimators, and better prediction accuracy. His research is highly interdisciplinary in that it involves statistical theory, bioinformatics, high-performance computing and biomedical sciences

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David Hockenbery , MD

Email: dhockenb@fredhutch.org

Phone: (206) 667-4611

Dr. Hockenbery specializes in gastroenterology and the genetic and biochemical mechanisms of apoptosis. Currently his group is focusing on: Investigation of the role of the c-myc transcription factor in bioenergetic regulation in cell growth and division, neoplastic transformation and apoptosis; Analysis of cell signaling and transcriptional responses to nutrient excess, employed in cells susceptible to neoplastic transformation.

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Noah Hoffman , MD, PhD

Email: ngh2@uw.edu

Phone: (206) 598-7932

Dr. Hoffman's clinical interests and responsibilities include the development and application of software and processes for the collection, management, and display of data generated in the clinical laboratory. His research is focused on creating applications and algorithms to classify medically important microorganisms using biological sequence information.

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Marshall Horwitz , MD, PhD

Email: horwitz@uw.edu

Phone: (206) 616-4566

Dr. Marshall Horwitz is an internist and clinical medical geneticist whose research interests relate to genetic factors predisposing to hematopoietic malignancy and the clonal evolution of cancer. The major focus of his research centers on defining the genetic origins of cancers of the blood and using that as a paradigm for further understanding development. His laboratory employs genetic mapping and sequencing strategies to identify genes responsible for familial predisposition to leukemia, lymphoma, and bone marrow failure syndromes. In related work, Dr. Horwitz's laboratory has developed a new approach for mapping cell fate during development by inferring the order in which mutations accumulate in somatic tissues.

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Li Hsu , PhD

Email: lih@fredhutch.org

Phone: (206) 667-2854

Dr. Hsu's principal research area is statistical genomics. These include assessing familial aggregation using variable age at onset as disease outcomes, discovering latent genes via linkage and association, and characterizing the effect of the genes and their interaction with environmental risk factors on the time course of the disease. She has been involved in various studies, such as case-control population based family studies of early onset breast cancer and prostate cancer . She is also interested on performing high-dimensional data analysis on gene-set association analysis and network construction. Understanding the gene expression changes between tumor and normal tissues may help in clinical diagnosis and yielding useful biomarkers for early diagnosis.

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George Ioannou , B.M.B.Ch, MS, FAASLD

Email: George.Ioannou@va.gov

Dr. Ioannou's clinical and research interests include liver cancer, hepatitis C, non-alcoholic fatty liver disease, iron deficiency and iron overload.

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Brian Iritani , DVM, PhD

Email: biritani@u.washington.edu

Phone: (206) 221-3932

Dr. Iritani's lab is studying the Myc oncogene family, Myc proteins are deregulated in many types of cancers including breast, brain, colon cancers, and most leukemias and lymphomas. He is interested in understanding how these proteins normally function in the development and proliferation of lymphocytes, and how these functions are altered during oncogenic activation. Utilizing cDNA microarray technology, his lab has identified sets of genes that are regulated by Myc in primary lymphocytes both before and after transformation.

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Rachel Issaka , MD, MAS

Email: rissaka@fredhutch.org

Phone: (206) 667-1447

Dr. Issaka is a gastroenterologist at the Fred Hutchinson Cancer Research Center and the University of Washington. She specializes in the medical and endoscopic management of digestive diseases including cancer complications that affect the gastrointestinal system. In addition to working with patients with digestive diseases, Dr. Issaka is a health services researcher with the Hutchinson Institute for Cancer Outcomes Research (HICOR). She conducts research related to colon cancer screening, prevention, and implementation of interventions that decrease disparities and improve outcomes in colorectal cancer care.

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Andrew Kaz , MD

Email: akaz@fredhutch.org; andrewk@medicine.washington.edu

Phone: (206) 667-1067

Dr. Kaz is a UW acting assistant professor in the Department of Medicine, Division of Gastroenterology. Dr. Kaz studies epigenetic alterations in colon and esophageal cancer.

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