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Susan Bullman , PhD

Email: sbullman@fredhutch.org

Phone: (206) 667-3449

The Bullman Lab focuses firstly on understanding the translational impact of the tumor microbiota in human cancers, and secondly on the delineation of specific mechanisms involved in the pathogenesis of microbe-associated human cancers. They combine molecular microbiology, computational biology, biochemistry, and genetics to understand host-microbial interactions within the tumor microenvironment. Through such efforts, her lab seeks to make discoveries that have both a scientific and clinical impact in the emerging area of bacterial-associated malignancies. Bacterial agents that have a role in cancer initiation or progression provide a viable route for prevention and treatment of these cancers.

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Xiaoyu Chai , MS

Email: xchai@fredhutch.org

Phone: (206) 667-3004

Xiaoyu Chai's interests lie in the design of experiments such as A/B testing, factorial design, sampling, blocking, randomization, stratification, power and sample size calculation; statistical modeling such as generalized linear/non-linear/additive/penalized models, survival analysis, simulation, time series forecasting, clustering/segmentation, dimension reduction, hypothesis testing, feature selection; and machine learning such as bootstrap, cross-validation, Monte Carlo simulation, classification trees, bagging, random forests, boosting, support vector machines, neural networks, ensemble learning, parallel computing.

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Victor Chow , MD

Email: vchow@fredhutch.org

Phone: (206) 667-7731

Dr. Chow conducts clinical research in lymphoma utilizing combination approaches with cellular-based therapies.

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Deborah Donnell , PhD

Email: deborah@scharp.org

Phone: (206) 667-5661

Dr. Donnell is a Principal Staff Scientist in the Vaccine and Infectious Disease Institute (VIDI). She is the Principal Investigator of the HIV Prevention Trials Network Statistical and Data Management Center. The scientific faculty, drawing from the University of Washington Biostatistics department and the Population Sciences Program in VIDI, are responsible for the design and analysis of Phase III clinical trials to access the efficacy of biomedical and behavioral interventions to prevent the transmission of HIV

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Adam Drewnowski , PhD

Email: adamdrew@u.washington.edu

Phone: (206) 543-8016

Dr. Drewnowski's interests are in the characterization of dietary patterns, nutrition economics, spatial distribution of obesity rates; and in the development of new metrics to identify foods that are nutrient dense, affordable and sustainable. He currently examines social determinants of health, focusing on the mechanisms behind the observed social gradient in diet quality and body weight. He has developed new methods to estimate monetary costs of individual diets, opening the door to new research on diet quality in relation to diet cost; and his studies on healthy food access make use of GIS techniques and new methods on spatial epidemiology to determine who shops for food where, why, how far from home and for how much.

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Zhijun Duan , PhD

Email: zjduan@uw.edu

Phone: (206) 543-3363

Dr. Duan's research is focused on the relationship between the form and function of human genomes during development and tumorigenesis. One of the striking features of the eukaryotic nucleus is that chromosomes adopt preferred conformations that vary across different tissues and developmental stages.

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Marianne Dubard-Gault , MD, MS

Email: mdg2019@uw.edu

Dr. Dubard-Gault is the medical director of the Cancer Genetics Program at SCCA. Her main research interest is to better understand how genetic information influences patients’ decision-making about health care and life choices. She is also interested in exploring ways to help people better access medical genetic information, talk about it with their families and use that knowledge to make decisions that fit their goals.

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Paul Edlefsen , PhD

Email: pedlefse@scharp.org

Phone: (206) 667-4086

Dr. Edlefsen's research interests include statistical and computational methods for bioinformatics applications. He is also interested in statistical modeling techniques for genome science analysis.

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Evan Eichler , PhD

Email: eee@gs.washington.edu

Phone: (206) 543-9526

Dr. Eichler's long term research goal is to understand the evolution, pathology and mechanism(s) of recent gene duplication and DNA transposition within the human genome. His work involves the systematic discovery of these regions, the development of methods to assess their variation, the detection of signatures of rapid gene evolution and ultimately the correlation of this genetic variation with phenotypic differences within and between species.

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Michael Emerman , PhD

Email: memerman@fredhutch.org

Phone: (206) 667-5058

Dr. Emerman's Lab studies the molecular and evolutionary basis for the replication of HIV and related viruses, with an emphasis on the interaction of these viruses with their host cells. Our goal is to understand what determines resistance or vulnerability to current, past and potential viral diseases.

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Min Fang , MD, PhD

Email: fangm@uw.edu

Phone: (206) 288-1390

Dr. Fang's research focus is on the genomics and combinatorial genetics/epigenetics of human neoplasia. She is combining classical genetic approaches of mapping, karyotyping, and functional genetics with new genomic tools including microarray, comparative genome hybridization, and next-generation sequencing, to identify genetic and epigenetic aberrations in cancer that may serve as actionable biomarkers for treatment decision making for individual patients.

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Jordan Gauthier , MD, MSc

Email: jgauthier@fredhutch.org

Phone: (206) 667-2713

Much of Dr. Gauthier's research has been focused on improving outcomes for patients treated with BMT or CAR T-cell therapy. Through his work, he has identified factors that can help predict the success of CAR T-cell therapy for patients who have leukemia and lymphoma.

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Gustavo Glusman , PhD

Email: gustavo.glusman@systemsbiology.org

Phone: (206) 732-1273

Dr. Glusman uses computational approaches to investigate genome structure and evolution; multi-gene families; prediction and discovery of genes and transcripts; genes not coding for proteins; visualization of complex data; and image analysis. His algorithms are contributing to the discovery of genes that are not easily identified using standard procedures, to the interpretation of large-scale transcriptomic and genomic data, and to the study of disease genetics.

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Raphael Gottardo , PhD

Email: raph@rglab.org

Phone: (206) 667-4076

Dr. Gottardo is the principal investigator in the Gottardo Lab and Fred Hutch. His research focuses on developing methods and tools for high throughput, high dimensional experiments with applications in vaccine research and immunology. His team also works on flow cytometry, peptide microarrays, next generation sequencing, Bayesian inference and computation, and statistical computing.

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Taran Gujral , PhD, Msc

Email: tgujral@fredhutch.org

Phone: (206) 667-4149

Cells respond to external stimuli by activating nonlinear and highly interconnected networks of signaling proteins. Dr. Gujral's work focuses on understanding how these networks are wired in different cell types and how they influence response to growth factors or cytotoxic agents using both hypothesis driven and systems-based data-driven approaches. His lab combines approaches from molecular genetics with cell and systems biology to study a recently discovered Wnt5-Fzd2 signaling pathway in metastasis as well as cell-to-cell contact in regulating cell fate decisions.

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Brandon Hadland , MD, PhD

Email: bhadland@fredhutch.org

Phone: (206) 667-1095

Dr. Brandon Hadland is a hematologist/oncologist and stem cell transplantation expert who treats young patients in Seattle Children’s Hospital transplant service. His research focuses on the origin of hematopoietic stem cells, which give rise to blood and immune cells. He harnesses new technologies to simultaneously analyze gene activities across the many different cell types within the physical site where the stem cells evolve and to characterize interactions between those various cells. He aims to identify the specific biological signals that trigger the formation of blood stem cells. His ultimate goal is to generate new sources of blood stem cells that could one day be used to correct inherited, blood-based diseases.

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Evan Hall , MD, MPhil

Email: evanh@seattlecca.org

Phone: (206) 606-2496

Dr. Hall's research focuses on how to measure and improve quality of life for patients with cancer. His other areas of interest include physician-patient communication, the health economics of cancer and the benefits of novel modes of patient and caregiver social support, such as online communities.

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Patrick Heagerty , PhD, MS

Email: pheagert@fredhutch.org

Phone: (206) 667-2685

Dr. Heagery's research interests are Regression techniques for dependent data including marginal models and random effects models for longitudinal data, methods for categorical time series, and hierarchical models for categorical spatial data, statistical computing, and applications in epidemiology and ecology.

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David Hockenbery , MD

Email: dhockenb@fredhutch.org

Phone: (206) 667-4611

Dr. Hockenbery specializes in gastroenterology and the genetic and biochemical mechanisms of apoptosis. Currently his group is focusing on: Investigation of the role of the c-myc transcription factor in bioenergetic regulation in cell growth and division, neoplastic transformation and apoptosis; Analysis of cell signaling and transcriptional responses to nutrient excess, employed in cells susceptible to neoplastic transformation.

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