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Brian Iritani , DVM, PhD

Email: biritani@u.washington.edu

Phone: (206) 221-3932

Dr. Iritani's lab is studying the Myc oncogene family, Myc proteins are deregulated in many types of cancers including breast, brain, colon cancers, and most leukemias and lymphomas. He is interested in understanding how these proteins normally function in the development and proliferation of lymphocytes, and how these functions are altered during oncogenic activation. Utilizing cDNA microarray technology, his lab has identified sets of genes that are regulated by Myc in primary lymphocytes both before and after transformation.

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Gisele Ishak , MD

Email: ishakg@u.washington.edu

Phone: (206) 221-7872

Dr. Ishak is a pediatric radiologist with expertise in diagnostic radiology and neuroradiology.

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Mike Jensen , MD

Email: michael.jensen@seattlechildrens.org

Phone: (206) 667-1907

Dr. Jensen is a pediatric cancer researcher. He has developed a method of reprogramming the body's own immune system to kill cancer. This technique of genetically re-engineering an individuals T cells has proven to be safe and effective in the laboratory. His research promises a future of immunotherapy cancer cures without the devastating side effects of radiation and chemotherapy. He is now working to translate this breakthrough to children with cancer.

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Robin Jones , MD

Email: rjones@seattlecca.org

Phone: (206) 288-7439

Dr. Jones is an associate professor in the Division of Medical Oncology at the University of Washington School of Medicine. His area of expertise is the care and treatment of adult bone and soft tissue sarcomas which are cancers that develop in tissues connecting, supporting or surrounding other structures and organs of the body. Dr. Jones specializes in hemangiopericytomas and chordomas, adult bone and soft tissue sarcoma, Phase I clinical trials, and breast cancer.

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Hans-Peter Kiem , MD, PhD

Email: hkiem@fredhutch.org

Phone: (206) 667-4425

Dr. Kiem is experienced in pre-clinical and clinical studies involving stem cell biology including hematopoietic stem cell transplantation, gene therapy, and, more recently, induced pluripotent stem cells. As the Director of the preclinical and clinical vector program, Dr. Kiem is an expert in the generation and production of most viral and nonviral gene transfer techniques. His group has developed many different retroviral vectors and developed optimized lentivirus-mediated gene transfer conditions for hematopoietic stem cells. Dr. Kiem's research focus has been the study of stem cell biology and cell engineering with applications involving genetic and infectious diseases, such as HIV, and cancer, in particular glioblastoma. He also has extensive experience in studying stem cell biology and his pioneering work in gene transfer in large animal models, including the nonhuman primate model of AIDS, has led to several successful gene and stem cell therapy trials. Dr. Kiem also has significant knowledge in induced pluripotent stem cells (iPSCs), especially using nonhuman primate iPSCs, which hold a promising potential for improving safety in model human applications for the treatment blood stem cell and bone marrow related diseases.

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Edward Kim , MD

Email: edykim@uw.edu

Phone: (206) 598-4100

Dr. Kim is a radiation oncologist who specializes in the treatment of gastrointestinal cancers, breast cancer, sarcoma, and brain and central nervous system cancers.

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Linda Ko , PhD, MPH

Email: lko@fhcrc.org

Phone: (206) 667-7182

Dr. Ko is the director of the Center for Health Communication Intervention (CHEALCI). She is a behavioral scientist with expertise in the development, testing, and evaluation of health communication strategies. Her work draws from the discipline of communication, marketing, social epidemiology, and social and behavioral sciences. Her research aims to understand community behavior within the socio-cultural context, develop interventions that will address those behaviors and translate knowledge through community-based participatory research.

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J. Nathan Kutz , PhD

Email: kutz@amath.washington.edu

Phone: (206) 685-3029

Professor Kutz is especially interested in a unified approach to applied mathematics which includes modeling, computation, and analysis. His primary interest is in connecting state-of-the-art data methods with complex systems. Such integration is particular important across the physical, engineering and biological sciences. In context of biological applications, Kutz has developed such methods for the characterization and control of neuro-sensory systems (insect olfaction and the dynamics of the nematode c. elegans) and traumatic brain injury (networks of neurons).

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Warren Ladiges , DVM, MS

Email: wladiges@u.washington.edu

Phone: (206) 685-3260

Dr. Ladiges uses mice to study the biology of aging and cancer. Co-creator of the CCRX (Cancer Consortium Xenograft Resource) which provides PDX models and tumor fragments of patient-derived samples for research.

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Jonathan (Jon) Liu , PhD, MS

Email: jonliu@uw.edu

Phone: (206) 543-5339

Dr. Liu's work focuses on developing optical strategies for biomedical diagnostics and therapy. These endeavors require multi-disciplinary advances in optical devices, contrast agents, image processing, and preclinical/clinical studies. For example, over the past few years, our lab has published on the simulation and development of a miniaturized advanced volumetric microscopy technology to enable real-time point-of-care pathology, as well as the development of molecularly targeted contrast agents to guide the surgical resection of tumors. These complementary technologies have the potential to revolutionize patient care by providing surgeons with a real-time alternative to invasive biopsy and frozen-sectioning pathology for confirming the status of tissues at the final stages of surgery. In addition, our lab is developing spectral imaging devices in conjunction with multiplexed Raman nanoparticles for the endoscopic visualization of large panels of disease biomarkers. This technology for the rapid molecular phenotyping of tissues has the potential to improve the early detection and surgical treatment of cancers, as well as to guide personalized therapies.

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Simon Lo , MD; Ch.B; FACR

Email: simonslo@uw.edu

Dr. Lo is a nationally and internationally renowned clinician, scholar and expert in advanced stereotactic radiation therapy techniques in brain tumors and tumors outside the CNS. In addition to his extensive expertise in CNS tumors, Dr. Lo has also been on the leading edge of expanding image-guided stereotactic radiation techniques beyond the brain to multiple other tumor sites, and his work has set the standard in clinical applications and care of patients in this area. He has made major contributions to the advancement of these innovative treatment techniques, translating them and increasing their efficacy and therapeutic ratio.

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Lawrence (Larry) MacDonald , PhD

Email: macdon@uw.edu

Phone: (206) 543-3653

Dr. MacDonald's research involves transforming newly established core technologies into imaging systems that enhance and/or expand medical imaging in application-specific and general-purpose SPECT, PET, and CT scanners. He works to improve existing scanners by trying to quantify the limitations of existing methods on final image quality, modeling how improvements to the underlying detector methods will affect final images, then attempting to confirm predictions with measured data.

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Desiree Marshall , MD

Email: damarsh@uw.edu

Phone: (206) 598-6462

Dr. Marshall’s clinical specialties are autopsy pathology and neuropathology. In addition to clinical autopsy pathology and diagnostic autopsy neuropathology, she is Medical Director of Autopsy and After Death Services for UW-Medicine Hospitals. As a board certified forensic pathologist, she directs the forensic neuropathology conference at King County Medical Examiner’s Office. Her research interests include neurodegeneration, neuropathology of Traumatic Brain Injury (TBI) and Chronic Traumatic Encephalopathy (CTE), and neuropathology of pediatric non-accidental trauma. Dr. Marshall’s main research effort is focused on the Pacific Northwest Brain Donor Network (PNBDN), which is a product of a regional collaborative effort to better understand the effects of military-related TBI.

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Tresa McGranahan , MD, PhD

Email: tresa@uw.edu

Dr. McGranahan is an expert in the care of patients with brain tumors as well as patients with cancer that have spread to the brain or spinal cord from other parts of the body. She also specializes in the effects of cancer and cancer treatments on the nervous system. Her clinical interests are in primary brain tumors, brain metastases, chemotherapy induced neuropathy and paraneoplastic disorders. Her research interests include clinical trials for primary and metastatic brain and spinal tumors.

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Martin McIntosh , PhD

Email: mmcintos@fredhutch.org

Phone: (206) 667-4612

Dr. McIntosh focuses on identifying the role of transcriptional and translational changes in cancer that lead to the formation of tumor antigens (neoantigens) and an adaptive immune response, primarily in ovarian and lung cancer. Once found our goal is to exploit immune-based approaches to kill the malignant cells that harbor the immunogenic molecular alterations, or to prevent the cancer using tumor vaccines.

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Andrew Mhyre , PhD

Email: amhyre@fhcrc.org

Phone: (206) 667-3047

Dr. Mhyre's research is focused on the discovery of new treatment options for rare diseases. His work focuses on throughput screening, in vitro biology, medicinal chemistry, DMPK and in vivo biology to progress to IND filing.

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Cecilia Moens , PhD

Email: cmoens@fredhutch.org

Phone: (206) 667-5627

Dr. Moens lab studies the early development of the nervous system, using the transparent zebrafish embryo as a model system. Interests in her lab include the cellular mechanisms of neuroepithelial morphogenesis, the role of the planar cell polarity (PCP) pathway in directed neuron migration, and the mechanism of electrical synapse formation in the well-characterized neural circuit that drives the larval escape response. A new cancer project in the lab takes advantage of the transparency of the larval fish to visualize at high resolution the metastatic behaviors of human melanoma cells as they interact with macrophages and endothelial cells in the tumor microenvironment.

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Beth Mueller , DrPH

Email: bmueller@fredhutch.org

Phone: (206) 667-4903

Dr. Mueller studies the roles of maternal, gestational, and early life factors and early environmental exposures in the occurrence of childhood cancer and autoimmune diseases. Her studies include: reproductive history in relation to cancer and cancer survival in women; reproductive outcomes among male and female childhood cancer survivors; maternal, gestational, and early life factors and early environmental exposures in relation to reproductive outcomes such as malformations, fetal death, low birth weight, and preterm delivery; and improving exposure assessment methods in epidemiologic studies of prenatal and childhood exposures.

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Andrew Oberst , Ph.D.

Email: oberst@uw.edu

Phone: (206) 221-7316

Dr. Oberst's research focuses on understanding how different forms of cell death occur, and how they influence immune responses in vivo. Multicellular organisms are complex communities cooperating of cells, and the death of some cells is required for the community to survive and thrive. His work studies the effect of each type of cell death in vivo, with the goal of understanding their role in processes such as inflammation, autoimmunity, tumor suppression, and immune responses to pathogen infection.

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Jeffrey Ojemann , MD

Email: jojemann@u.washington.edu

Phone: (206) 987-4240

Dr. Ojemann's clinical interests include surgical treatment of epilepsy and of tumors near the brain tissue needed for thinking and speaking. His lab work focuses on using electrocorticography (ECoG) to answer basic neuroscience questions as well as to develop tools for clinical and rehabilitative applications. ECoG, which is used for long-term clinical monitoring of epilepsy patients, provides a unique opportunity to collect intracranial cortical data from awake, behaving humans. The group, under the direction of Dr. Ojemann, represents researchers from a wide range of backgrounds including neurosurgery, neurology, rehabilitative medicine, engineering, neuroscience, and physics. A major focus of the group is brain-computer interfaces; current projects include learning mechanisms, tactile feedback, and recursive stimulation. Also under investigation are more fundamental questions about cortical representation of simple and complex hand movements, the dynamics of cognition, language, and higher-order nonlinear interactions between brain areas. Other projects include integration of ECoG and fMRI and studies of temporal lobe epilepsy.

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