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q=Colorectal

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Edward Kim , MD

Email: edykim@uw.edu

Phone: (206) 598-4100

Dr. Kim is a radiation oncologist who specializes in the treatment of gastrointestinal cancers, breast cancer, sarcoma, and brain and central nervous system cancers.

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Linda Ko , PhD, MPH

Email: lko@fhcrc.org

Phone: (206) 667-7182

Dr. Ko is the director of the Center for Health Communication Intervention (CHEALCI). She is a behavioral scientist with expertise in the development, testing, and evaluation of health communication strategies. Her work draws from the discipline of communication, marketing, social epidemiology, and social and behavioral sciences. Her research aims to understand community behavior within the socio-cultural context, develop interventions that will address those behaviors and translate knowledge through community-based participatory research.

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Sharon Kwan , MD

Email: shakwan@uw.edu

Phone: (206) 543-5972

Dr. Kwan is an interventional radiologist. She performs minimally invasive procedures using image-guidance, with a clinical focus in the treatment of liver cancer and uterine fibroids. Dr. Kwan's research interests include healthcare utilization, comparative effectiveness, hepatocellular carcinoma, transarterial chemoembolization; Y-90 radioembolization and transjugular intrahepatic portosystemic shunts.

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Johanna Lampe , PhD

Email: jlampe@fredhutch.org

Phone: (206) 667-6580

Dr. Lampe's research interests relate to the mechanisms by which components of diet, particularly constituents of plant food, alter susceptibility to and risk of cancer. Her primary research activities include using controlled dietary interventions in humans to determine how individual variation in biochemical response to high-plant food diets (e.g., biotransformation enzyme modulation, colonic environment changes) may explain differences in disease risk. The Lampe lab also studies the effect of diet on gut microbial community and the relationship of the gut microbiome to biomarkers of cancer risk.

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Paul Lampe , PhD

Email: plampe@fredhutch.org

Phone: (206) 667-4123

Dr. Lampe and his lab investigate the control of cell growth both at the cell biological/ mechanistic level and through cancer biomarker discovery. He studies the cell biology connecting gap junctions and intercellular communication (GJIC) with the control of cell growth, the cell cycle and, how the relationship is disrupted during carcinogenesis. To perform these studies he utilizes a variety of cell, molecular and biochemical techniques including GFP chimeras to monitor gap junctions in living cells.

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Georg Luebeck , PhD

Email: gluebeck@fredhutch.org

Phone: (206) 667-4282

Dr. Luebeck focuses primarily on the development of biomathematical descriptions of carcinogenesis, the identification and characterization of relevant spatio-temporal scales, and their impact on cancer incidence. The ultimate goal of his research is to being able to model/optimize the benefits of cancer screening, prevention, and intervention - based on a biological description of the natural history of cancer.

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Lillian Maggio-Price , MD, PhD

Email: lmprice@uw.edu

Phone: (206) 685-3257

Dr. Maggio-Price’s research centers on microbial triggers of inflammation and cancer in the gastrointestinal tract and associated immunologic responses. Specifically, her laboratory has used genetically modified mutant mouse models to study the role of bacterial organisms, such as Helicobacter spp. to initiate and sustain dysregulated immune responses believed to characterize inflammatory bowel disease. Inflammatory bowel diseases in man (Crohn’s Disease and Ulcerative Colitis) are characterized by chronic and relapsing inflammatory intestinal disorders and are associated with a higher risk of colon cancer. Additionally, Maggio-Price's lab has been studying the effects of altered dietary vitamin D on colitis and colitis-associated colon cancer using several unique mouse models including a bacterial-triggered mouse model developed in her lab. Dr. Price has been involved in setting up the new Gnotobiotic Animal Core at the University of Washington

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Anne McTiernan , MD, PhD

Email: amctiern@fredhutch.org

Phone: (206) 667-7979

Dr. McTiernan's research focuses on identifying ways to prevent new or recurrent cancer with a particular focus on weight control, physical activity, and chemoprevention. She leads transdisciplinary research to elucidate the pathways linking components of energy balance to the cancer process. The five projects and four cores incorporate several different study designs, with contributions of scientists from medicine, cell biology, animal models, immunology, biostatistics, mathematics, exercise physiology, and behavioral science.

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Andrew Mhyre , PhD

Email: amhyre@fhcrc.org

Phone: (206) 667-3047

Dr. Mhyre's research is focused on the discovery of new treatment options for rare diseases. His work focuses on throughput screening, in vitro biology, medicinal chemistry, DMPK and in vivo biology to progress to IND filing.

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Polly Newcomb , PhD, MPH

Email: pnewcomb@fredhutch.org

Phone: (206) 667-3476

As a cancer epidemiologist, Dr. Newcomb focuses her research on the identification of modifiable risk factors for common cancers, particularly breast and colon cancer. Since many of these risk factors appear to have only modest magnitudes of effect, more precisely identifying susceptible individuals defined by genes, epigenetic changes, or personal characteristics such as body size may help direct investigations in the population, laboratory and clinic. She studies these risk factors and their relationship to survival after diagnosis and with longevity.

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Andrew Oberst , Ph.D.

Email: oberst@uw.edu

Phone: (206) 221-7316

Dr. Oberst's research focuses on understanding how different forms of cell death occur, and how they influence immune responses in vivo. Multicellular organisms are complex communities cooperating of cells, and the death of some cells is required for the community to survive and thrive. His work studies the effect of each type of cell death in vivo, with the goal of understanding their role in processes such as inflammation, autoimmunity, tumor suppression, and immune responses to pathogen infection.

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Susan Parkhurst , PhD

Email: susanp@fredhutch.org

The Parkhurst lab is interested in the actions of both maternally and zygotically contributed gene products that govern proper embryonic development in Drosophila. Building tissues and organs during embryogenesis involves a series of exquisite morphogenetic processes including precisely orchestrated tissue contractions, foldings and migrations. Many of the naturally occurring epithelial movements that shape the embryo during morphogenesis are similar to those employed in the wound healing response and to cell behaviors in tumor progression. The Parkhurst lab uses developmental, genetic, cell biological, and molecular approaches to look at different regulatory mechanisms and pathways required for proper Drosophila embryonic development. Their current efforts are divided between studies of: (1) molecular and cellular mechanisms of single cell and multicellular (tissue) wound repair; (2) actin and microtubule cytoskeleton dynamics mediated by the Rho1 small GTPase and its effectors Wash, Capu, and Spire; and (3) nuclear architecture and organization.

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Ulrike Peters , PhD, MPH

Email: upeters@fredhutch.org

Phone: (206) 667-2450

Dr. Peter's research interests center on the genetic and molecular epidemiology of common complex diseases, including cancer, obesity, type 2 diabetes, and stroke, as well as intermediate traits, including inflammation, glucose, or insulin. She is studying the impact of common and rare genetic variants across the entire genome, as well as interactions between genetic variants and environmental factors (such as diet, exercise, smoking, aspiring use).

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Amanda Phipps , PhD

Email: aphipps@fredhutch.org

Phone: (206) 667-7741

Dr. Phipps's research interests span the fields of cancer epidemiology, molecular epidemiology, and clinical epidemiology. Her current projects focus on the relationship between modifiable lifestyle factors (e.g., smoking, obesity) and survival in individuals with biologically-distinct subtypes of colorectal cancer. She also has an interest in molecular subtypes of breast cancer, particularly in risk factors for the poor-prognosis triple-negative subtype of breast cancer.

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Seth Pollack , MD

Email: spollack@fredhutch.org

Phone: (206) 667-6629

Dr. Pollack is a medical oncologist who treats adult patients with sarcoma. His clinical interests include sarcoma, and immune-based therapies.

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John Potter , MD, PhD

Email: jpotter@fredhutch.org

Phone: (206) 667-4683

Dr. Potter is interested in the etiology and prevention of cancer, particularly colorectal and pancreatic cancer. He also studies the aspects of diet and physical activity that reduce risk - notably plant foods and the many compounds they contain that may act to slow or reverse the process of carcinogenesis. In addition, he studies the interaction of genes and environment in the etiology of cancer.

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Bhagwat Prasad , PhD

Email: bhagwat@uw.edu

Phone: (206) 221-3035

Dr. Prasad's research is focused on quantitative pharmacoproteomics, pharmacometabolomics, mechanisms of inter-individual variability of transporters/metabolizing enzymes in human tissues, and physiologically-based pharmacokinetic modeling.

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Colin Pritchard , MD, PhD

Email: cpritch@uw.edu

Phone: (206) 598-8400

Dr. Pritchard specializes in cancer molecular diagnostics development for precision medicine and microRNA as blood-based biomarkers and he helped to develop UW-OncoPlex (a molecular test which can inform diagnosis, prognosis, and/or treatment plans for patients). His research is focused on two main areas related to cancer molecular diagnostics: microRNA as blood-based biomarkers, and cancer molecular diagnostics development for precision medicine.

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Martin Prlic , PhD

Email: mprlic@fredhutch.org

Phone: 206-667-2216

The connecting theme throughout Dr. Prlic's research career has been his interest in lymphocyte differentiation. This started initially at the University of Salzburg, Austria, followed by his Ph.D. training at the University of Minnesota in the laboratory of Dr. Stephen Jameson. As a postdoctoral fellow at the University of Washington, he had the opportunity to establish his own T cell and NK cell research projects in the laboratory of Dr. Michael Bevan with a focus on T cell and NK cell responses in the context of infectious diseases. When Dr. Prlic started his own laboratory at the Fred Hutchinson Cancer Research Center in 2011, he continued his T cell work in the context of vaccination and infectious diseases. Through a close collaboration with Dr. Raphael Gottardo (FHCRC) his lab has started to examine human T cell subsets from blood and mucosal tissues using different single-cell gene expression analysis strategies. Dr. Prlic's overall goal is to understand how T cell fate and function are controlled in healthy and inflamed tissues and following infection with HIV to identify how these responses can be manipulated for therapeutic purposes.

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Peter Rabinovitch , MD, PhD

Email: petersr@u.washington.edu

Phone: (206) 667-3761

Dr. Rabinovitch's laboratory research is focused on the use of transgenic mouse models and pharmacological treatments to examine the effects of cell signaling, protein homeostasis and reactive oxygen species (ROS) on lifespan and healthspan. He is also interested in the study of DNA damage and genomic instability in aging and in neoplastic progression.

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