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Jonathan (Jon) Liu , PhD, MS

Email: jonliu@uw.edu

Phone: (206) 543-5339

Dr. Liu's work focuses on developing optical strategies for biomedical diagnostics and therapy. These endeavors require multi-disciplinary advances in optical devices, contrast agents, image processing, and preclinical/clinical studies. For example, over the past few years, our lab has published on the simulation and development of a miniaturized advanced volumetric microscopy technology to enable real-time point-of-care pathology, as well as the development of molecularly targeted contrast agents to guide the surgical resection of tumors. These complementary technologies have the potential to revolutionize patient care by providing surgeons with a real-time alternative to invasive biopsy and frozen-sectioning pathology for confirming the status of tissues at the final stages of surgery. In addition, our lab is developing spectral imaging devices in conjunction with multiplexed Raman nanoparticles for the endoscopic visualization of large panels of disease biomarkers. This technology for the rapid molecular phenotyping of tissues has the potential to improve the early detection and surgical treatment of cancers, as well as to guide personalized therapies.

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Lawrence (Larry) MacDonald , PhD

Email: macdon@uw.edu

Phone: (206) 543-3653

Dr. MacDonald's research involves transforming newly established core technologies into imaging systems that enhance and/or expand medical imaging in application-specific and general-purpose SPECT, PET, and CT scanners. He works to improve existing scanners by trying to quantify the limitations of existing methods on final image quality, modeling how improvements to the underlying detector methods will affect final images, then attempting to confirm predictions with measured data.

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Kathleen Malone , PhD, MPH, BSW

Email: kmalone@fredhutch.org

Phone: (206) 667-4632

Dr. Malone's major research focuses on the epidemiology of breast cancer, with foci on the etiologic and genetic determinants of developing breast cancer as well as predictors of outcomes after breast cancer, particularly second primaries, recurrences, and survival.

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Renato Martins , MD, MPH

Email: rgmart@uw.edu

Phone: (206) 288-2048

Dr. Martins is a medical oncologist who specializes in lung cancer, head and neck cancer, clinical trial design, and new drug development.

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Chris Miller , PhD

Email: cpmiller@u.washington.edu

Phone: (206) 543-3363

Dr. Miller works in Dr. Hootie Warren’s lab and is spearheading the development of a human microphysiological “tumor-on-a-chip” for accelerating investigation of the barriers to T cell immunotherapy in the solid tumor microenvironment, including the extracellular matrix and the vascular endothelium. Efforts are focused on the most common type of kidney cancer, renal cell carcinoma. Dr. Miller has experience developing the human 3D vascularized renal-cell-carcinoma-on-a-chip that faithfully recapitulates angiogenic blood vessel sprouting in the presence of patient tumor spheroids but not normal-adjacent kidney cells. The tumor-on-a-chip approach is broadly applicable to a variety of solid tumors.

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Carolyn Nakisige , M.D.

Email: carolynnakisige@yahoo.com

Phone: +256-712659651

Carolyn Nakisige is interested in cervical cancer prevention and management in limited resource settings.

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Polly Newcomb , PhD, MPH

Email: pnewcomb@fredhutch.org

Phone: (206) 667-3476

As a cancer epidemiologist, Dr. Newcomb focuses her research on the identification of modifiable risk factors for common cancers, particularly breast and colon cancer. Since many of these risk factors appear to have only modest magnitudes of effect, more precisely identifying susceptible individuals defined by genes, epigenetic changes, or personal characteristics such as body size may help direct investigations in the population, laboratory and clinic. She studies these risk factors and their relationship to survival after diagnosis and with longevity.

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Paul Nghiem , MD, PhD

Email: pnghiem@uw.edu

Phone: (206) 221-2632

Dr. Nghiem’s focus is on skin cancer. He directs a research lab concentrated on basic, clinical and translational research on how sunlight causes skin cancer. A particular emphasis for his patient care and research is Merkel cell carcinoma, a cancer three times more lethal than malignant melanoma. This aggressive skin cancer is typically caused by a recently discovered polyomavirus, and for it to develop it must “escape” from normal immune recognition of this virus. These recent discoveries open exciting avenues of research to improve patient care for those suffering from this disease.

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Andrew Oberst , Ph.D.

Email: oberst@uw.edu

Phone: (206) 221-7316

Dr. Oberst's research focuses on understanding how different forms of cell death occur, and how they influence immune responses in vivo. Multicellular organisms are complex communities cooperating of cells, and the death of some cells is required for the community to survive and thrive. His work studies the effect of each type of cell death in vivo, with the goal of understanding their role in processes such as inflammation, autoimmunity, tumor suppression, and immune responses to pathogen infection.

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Jeffrey Ojemann , MD

Email: jojemann@u.washington.edu

Phone: (206) 987-4240

Dr. Ojemann's clinical interests include surgical treatment of epilepsy and of tumors near the brain tissue needed for thinking and speaking. His lab work focuses on using electrocorticography (ECoG) to answer basic neuroscience questions as well as to develop tools for clinical and rehabilitative applications. ECoG, which is used for long-term clinical monitoring of epilepsy patients, provides a unique opportunity to collect intracranial cortical data from awake, behaving humans. The group, under the direction of Dr. Ojemann, represents researchers from a wide range of backgrounds including neurosurgery, neurology, rehabilitative medicine, engineering, neuroscience, and physics. A major focus of the group is brain-computer interfaces; current projects include learning mechanisms, tactile feedback, and recursive stimulation. Also under investigation are more fundamental questions about cortical representation of simple and complex hand movements, the dynamics of cognition, language, and higher-order nonlinear interactions between brain areas. Other projects include integration of ECoG and fMRI and studies of temporal lobe epilepsy.

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Susan Parkhurst , PhD

Email: susanp@fredhutch.org

The Parkhurst lab is interested in the actions of both maternally and zygotically contributed gene products that govern proper embryonic development in Drosophila. Building tissues and organs during embryogenesis involves a series of exquisite morphogenetic processes including precisely orchestrated tissue contractions, foldings and migrations. Many of the naturally occurring epithelial movements that shape the embryo during morphogenesis are similar to those employed in the wound healing response and to cell behaviors in tumor progression. The Parkhurst lab uses developmental, genetic, cell biological, and molecular approaches to look at different regulatory mechanisms and pathways required for proper Drosophila embryonic development. Their current efforts are divided between studies of: (1) molecular and cellular mechanisms of single cell and multicellular (tissue) wound repair; (2) actin and microtubule cytoskeleton dynamics mediated by the Rho1 small GTPase and its effectors Wash, Capu, and Spire; and (3) nuclear architecture and organization.

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Upendra Parvathaneni , MD

Email: upendra@u.washington.edu

Phone: (206) 598-4100

Dr. Parvathaneni is a radiation oncologist who specializes in head and neck cancer treatment. His clinical expertise is in head and neck radiotherapy, intensity-modulated radiotherapy (IMRT), neutron therapy, salivary gland malignancies, Merkel Cell carcinomas, skin cancer, and melanoma. His research interests are focused on newer treatment modalities and techniques.

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Jonathan Perkins , DO

Email: jonathan.perkins@seattlechildrens.org

Phone: 206 526-2115

Dr. Perkins researches vascular anomalies of which some are solid.

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Colin Pritchard , MD, PhD

Email: cpritch@uw.edu

Phone: (206) 598-8400

Dr. Pritchard specializes in cancer molecular diagnostics development for precision medicine and microRNA as blood-based biomarkers and he helped to develop UW-OncoPlex (a molecular test which can inform diagnosis, prognosis, and/or treatment plans for patients). His research is focused on two main areas related to cancer molecular diagnostics: microRNA as blood-based biomarkers, and cancer molecular diagnostics development for precision medicine.

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Martin Prlic , PhD

Email: mprlic@fredhutch.org

Phone: 206-667-2216

The connecting theme throughout Dr. Prlic's research career has been his interest in lymphocyte differentiation. This started initially at the University of Salzburg, Austria, followed by his Ph.D. training at the University of Minnesota in the laboratory of Dr. Stephen Jameson. As a postdoctoral fellow at the University of Washington, he had the opportunity to establish his own T cell and NK cell research projects in the laboratory of Dr. Michael Bevan with a focus on T cell and NK cell responses in the context of infectious diseases. When Dr. Prlic started his own laboratory at the Fred Hutchinson Cancer Research Center in 2011, he continued his T cell work in the context of vaccination and infectious diseases. Through a close collaboration with Dr. Raphael Gottardo (FHCRC) his lab has started to examine human T cell subsets from blood and mucosal tissues using different single-cell gene expression analysis strategies. Dr. Prlic's overall goal is to understand how T cell fate and function are controlled in healthy and inflamed tissues and following infection with HIV to identify how these responses can be manipulated for therapeutic purposes.

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Daniel Raftery , PhD

Email: draftery@uw.edu

Phone: (206) 543-9709

Dr. Raftery is an expert in the field of metabolomics, the study of small molecules involved in the metabolism of biological systems, cells, animals and humans. His research focuses on the development of advanced analytical tools and statistical methodologies for profiling metabolites in complex biological samples. He has applied these analytic approaches and demonstrated their utility for early detection of several types of cancer, as well as their utility in researching diabetes and heart disease.

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Scott Ramsey , MD, PhD

Email: sramsey@fredhutch.org

Phone: (206) 667-7846

Dr. Ramsey is a member of the Public Health Sciences Division at Fred Hutch. His research focus is comparative effectiveness analysis; cost effectiveness analysis, health economics, and cancer outcomes research. He is a doctors and health economists who has lead studies on patterns of care, costs and cost-effectiveness of treatments for lung, colorectal and prostate cancer.

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Cristina Rodriguez , MD

Email: rodrigcr@uw.edu

Phone: (206) 288-7485

Dr. Rodriguez designs, conducts, and reports on clinical trials. She is particularly interested in the incorporation of targeted therapies into current treatment standards for locally advanced squamous cell carcinomas of the head and neck, salivary gland cancers, and radioactive iodine-refractory thyroid cancers.

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Ann Roman , PhD

Email: aroman@fredhutch.org

Dr. Roman’s main focus is on the mechanism of HPV pathogenecity, addressing the interplay between the virus and its host cell in undifferentiated and differentiated conditions. She primarily studies this in low-risk HPV, those causing benign disease, to better understand what is needed for replication of all HPVs versus what is unique to the high-risk HPVs, those that contribute to the development of anogenital cancers. She also studies the impact of high-risk HPV gene products on angiogenesis, the recruitment of a blood supply to the cells expressing these viral genes.

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Jay Rubinstein , MD, PhD

Email: rubinj@u.washington.edu

Phone: (206) 616-6655

Dr. Rubinstein has published over 110 peer reviewed articles in both clinical and basic science journals and has mentored 18 predoctoral and postdoctoral trainees in basic and translational research, as well as, providing clinical training to a large number of otolaryngology residents and fellows. His laboratory studies models of signal processing in and perception with cochlear implants and is collaborating in the development of a vestibular implant. Rubinstein's clinical interests encompass management of tumors of the lateral skull base, as well as, auditory, vestibular and facial nerve disorders

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