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q=Mentoring

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Qinghang (Chris) Liu , PhD

Email: qcliu@uw.edu

Phone: (206) 685-9133

Dr. Liu's research is focused on defining novel signaling and transcriptional regulatory mechanisms that underlie cardiac hypertrophy and heart failure. In his lab, they take multi-disciplinary approaches including biochemistry, molecular and cell biology, molecular genetics, and system physiology to understand the molecular basis of heart disease using model systems ranging from yeast cell system to genetic mouse models.

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Yajuan Liu , PhD

Email: yajuan@uw.edu

Dr. Liu's research lab is currently focused on the following four projects: (1)Developing DNA sequence-based characterization of breakpoints of chromosome translocations/inversions in cancer using next generation sequencing. (2) Identifying new markers for Hepatitis C-associated hepatocellular carcinoma. (3) Correlating genetic alterations detected using genomic microarray and next generation sequencing with histology and clinical outcome in melanocytic neoplasms. (4) Use of genomic microarray analysis to rule in/out oncocytoma of the kidney in needle core biopsies. Dr. Liu's main goals are to identify cancer biomarkers and novel therapeutic targets and to develop molecular diagnostics using both conventional genetics methods and new genomic approaches to aid in precision diagnostics for personalized care.

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Georg Luebeck , PhD

Email: gluebeck@fredhutch.org

Phone: (206) 667-4282

Dr. Luebeck focuses primarily on the development of biomathematical descriptions of carcinogenesis, the identification and characterization of relevant spatio-temporal scales, and their impact on cancer incidence. The ultimate goal of his research is to being able to model/optimize the benefits of cancer screening, prevention, and intervention - based on a biological description of the natural history of cancer.

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David MacPherson , PhD

Email: dmacpher@fredhutch.org

Phone: (206) 667-6464

Dr. MacPherson studies two tumor types, small cell lung carcinoma (SCLC) and retinoblastoma. He conducts genomic analyses of human tumors to identify gene mutations that may contribute to tumor initiation, progression and metastasis. His goal is to understand the mechanisms through which cancer-mutated genes drive tumorigenesis, small cell lung carcinoma (SCLC) and retinoblastoma.

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Harmit Malik , PhD

Email: hsmalik@fredhutch.org

Phone: (206) 667-5204

Dr. Malik is interested in a variety of problems that could all be classified under the genetics of evolutionary conflict. He studies rapidly evolving proteins as a hallmark of this kind of conflict, hoping to better understand the molecular nature of the conflict, as well as uncover previously unrecognized sources of conflict. His lab is currently working on several rapidly evolving projects including centromeres and heterochromatin, nuclear import and variant histones, and innate defense strategies against retroviruses

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Chris Miller , PhD

Email: cpmiller@u.washington.edu

Phone: (206) 543-3363

Dr. Miller works in Dr. Hootie Warren’s lab and is spearheading the development of a human microphysiological “tumor-on-a-chip” for accelerating investigation of the barriers to T cell immunotherapy in the solid tumor microenvironment, including the extracellular matrix and the vascular endothelium. Efforts are focused on the most common type of kidney cancer, renal cell carcinoma. Dr. Miller has experience developing the human 3D vascularized renal-cell-carcinoma-on-a-chip that faithfully recapitulates angiogenic blood vessel sprouting in the presence of patient tumor spheroids but not normal-adjacent kidney cells. The tumor-on-a-chip approach is broadly applicable to a variety of solid tumors.

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Beth Mueller , DrPH

Email: bmueller@fredhutch.org

Phone: (206) 667-4903

Dr. Mueller studies the roles of maternal, gestational, and early life factors and early environmental exposures in the occurrence of childhood cancer and autoimmune diseases. Her studies include: reproductive history in relation to cancer and cancer survival in women; reproductive outcomes among male and female childhood cancer survivors; maternal, gestational, and early life factors and early environmental exposures in relation to reproductive outcomes such as malformations, fetal death, low birth weight, and preterm delivery; and improving exposure assessment methods in epidemiologic studies of prenatal and childhood exposures.

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James (Jim) Mullins , PhD

Email: jmullins@u.washington.edu

Phone: (206) 732-6163

Dr. Mullins's lab uses the techniques of molecular, computational and virus biology to provide basic insights into the HIV-human host relationship in an effort to assist the fight to stop the AIDS pandemic. His team uses a variety of techniques to understand the implications of HIV's extraordinary genetic diversity for the pathogenesis of AIDS, with the intention of applying this information to the development of more effective therapies and vaccines. These techniques include virology; and molecular biological and statistical analysis of nucleotide sequences.

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Peter Nelson , MD

Email: pnelson@fredhutch.org

Phone: (206) 667-3377

Dr. Nelson is an oncologist specializing in therapies for early- and late-stage prostate cancer, pathology, and genome sciences. The focus of current work in the Nelson lab involves efforts to uncover how prostate cancer forms. The goal is to create tools to diagnose the onset of prostate cancer, develop prognostic strategies, and help develop more effective therapies for treating this disease.

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Patrick Paddison , PhD

Email: paddison@fredhutch.org

Phone: (206) 667-4312

Dr. Paddison's primary goal is to define the biological units of self-renewal, expansion, and lineage commitment in model stem cell systems, including: embryonic stem cells, hematopoietic stem cells, neural progenitor cells, and brain tumor initiating cells (i.e., brain tumor stem cells). His lab uses functional genomics to probe the underlying biology of mammalian stem and progenitor cells. Specifically, they are looking at glioblastoma as a model cancer system.

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Amanda Paulovich , MD, PhD

Email: apaulovi@fredhutch.org

Phone: (206) 667-1912

Dr. Paulovich is a medical oncologist by training whose research focuses on the study of human phenotypic variation. Her projects include, the development of high throughput, multiplexed technologies for targeted protein quantification in blood, plasma and solid tissues and their use to determine human phenotypic variation in the cellular response to DNA damage, and to elucidate the network of genes and pathways that buffer defects in this response.

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Ulrike Peters , PhD, MPH

Email: upeters@fredhutch.org

Phone: (206) 667-2450

Dr. Peter's research interests center on the genetic and molecular epidemiology of common complex diseases, including cancer, obesity, type 2 diabetes, and stroke, as well as intermediate traits, including inflammation, glucose, or insulin. She is studying the impact of common and rare genetic variants across the entire genome, as well as interactions between genetic variants and environmental factors (such as diet, exercise, smoking, aspiring use).

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Hong Qian , PhD

Email: qian@amath.washington.edu

Phone: (206) 543-2584

Dr. Qian's main research interest is the mathematical approach to and physical understanding of biological systems, especially in terms of stochastic mathematics and nonequilibrium statistical physics. In recent years, he has been particularly interested in a nonlinear, stochastic, open system approach to cellular dynamics. Similar population dynamic approach can be applied to other complex systems and processes, such as those in ecology, infection epidemics, and economics. He believes his recent work on the statistical thermodynamic laws of general Markov processes can have applications in economic dynamics and theory of values.

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Daniel Raftery , PhD

Email: draftery@uw.edu

Phone: (206) 543-9709

Dr. Raftery is an expert in the field of metabolomics, the study of small molecules involved in the metabolism of biological systems, cells, animals and humans. His research focuses on the development of advanced analytical tools and statistical methodologies for profiling metabolites in complex biological samples. He has applied these analytic approaches and demonstrated their utility for early detection of several types of cancer, as well as their utility in researching diabetes and heart disease.

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Scott Ramsey , MD, PhD

Email: sramsey@fredhutch.org

Phone: (206) 667-7846

Dr. Ramsey is a member of the Public Health Sciences Division at Fred Hutch. His research focus is comparative effectiveness analysis; cost effectiveness analysis, health economics, and cancer outcomes research. He is a doctors and health economists who has lead studies on patterns of care, costs and cost-effectiveness of treatments for lung, colorectal and prostate cancer.

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Timothy Randolph , PhD

Email: trandolp@fredhutch.org

Phone: (206) 667-1079

Dr. Randolph's current research focuses on processing, classification and analysis of high-dimensional and/or functional data output from protein mass spectrometry, genetic assays and a variety of spectroscopies and imaging modalities. His other interests include methods for the analysis of networks used to describe gene and/or protein interactions.

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Thomas Richardson , MD, FACC

Email: thomasr@uw.edu

Phone: (206) 685-8488

Dr. Richardson's main area of research, graphical models, has developed at the interface between statistics and computer science, but has origins and applications in econometrics, epidemiology, genomics, psychology, and sociology. In other words, graphs (composed of vertices and edges) provide a language for formulating complex hypotheses.

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Harlan Robins , PhD

Email: hrobins@fredhutch.org

Phone: (206) 667-2571

Dr. Robins's research is computationally based and focuses on the adaptive immune system and its response to viral infection, with HIV a particular area of interest. Taking advantage of new high-throughput sequencing technology, in collaboration with experimental groups, we are isolating and sequencing millions of t-cell receptor VDJ rearrangements from different clonotypes.

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Jay Rubinstein , MD, PhD

Email: rubinj@u.washington.edu

Phone: (206) 616-6655

Dr. Rubinstein has published over 110 peer reviewed articles in both clinical and basic science journals and has mentored 18 predoctoral and postdoctoral trainees in basic and translational research, as well as, providing clinical training to a large number of otolaryngology residents and fellows. His laboratory studies models of signal processing in and perception with cochlear implants and is collaborating in the development of a vestibular implant. Rubinstein's clinical interests encompass management of tumors of the lateral skull base, as well as, auditory, vestibular and facial nerve disorders

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Walter Ruzzo , PhD

Email: ruzzo@cs.washington.edu

Phone: (206) 543-6298

Dr. Ruzzo's research is focused on development of computational methods and tools applicable to practical problems in molecular biology, an increasingly data-rich discipline. Recent work has focused on analysis of high throughput sequencing data, such as chromatin immunoprecipitation (ChIPseq) and transcriptomic (RNAseq) data, including development of new methods for mapping, assembly, bias correction, isoform quantitation, and motif discovery. New methods for finding noncoding RNA (ncRNA) genes are also being actively developed.

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