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Eric Holland , MD, PhD

Email: eholland@fredhutch.org

Phone: (206) 667-6117

Dr. Holland is a neurosurgeon and brain cancer researcher. His research goal is to address the molecular basis of brain tumors and develop new treatment approaches. His research focuses on developing mouse models of brain cancer that mimic how the disease behaves in patients. He has vast experience in conducting clinical trials in glioma patients and developing imaging strategies to follow mouse brain tumors as they develop a powerful system that is used to test promising new drugs.

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Sarah Holte , PhD

Email: sholte@fredhutch.org

Phone: (206) 667-6975

Dr. Holte's general work is focused in mathematical and statistical modeling of time-varying biological processes. Her current interests lie in differential and difference equations to model the biology of HIV and the immune system.

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Dick Hoskins , PhD, MPH

Email: rhoskins@uw.edu

Phone: (907) 317-6821

Dr. Hokins' main interest in public health practice concerns the impact of climate change on wildlife and human health and how they interact. He is a participant in the Fulbright Specialist Program working as requested in developing countries. His specific research interests include applications of geographic information systems to public health practice, spatial statistics, and environmental hazard assessment for wildlife.

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Jeffrey Houlton , MD

Email: jhoulton@uw.edu

Phone: (206) 543-5230

Dr. Houlton is a surgical oncologist who specializes in treating patients with head and neck cancers. His research focuses on clinical outcomes research related to microvascular reconstructive surgery, head & neck cancer treatment, and thyroid/parathyroid surgery.

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George Ioannou , B.M.B.Ch, MS, FAASLD

Email: George.Ioannou@va.gov

Dr. Ioannou's clinical and research interests include liver cancer, hepatitis C, non-alcoholic fatty liver disease, iron deficiency and iron overload.

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Teresa Kim , MD

Email: tkim5@uw.edu

Phone: (206) 221-8290

Dr. Kim is a Surgical Oncologist and UW Acting Assistant Professor of Surgery, with expertise in the surgical management of sarcomas, melanomas, and other cancers of the soft tissue, skin, and gastrointestinal tract. Her primary sites of practice are the University of Washington Medical Center, where she operates, and the Seattle Cancer Care Alliance, where she sees patients in clinic. Dr. Kim is a dedicated cancer surgeon who works with a multidisciplinary team of experts to provide individualized and outstanding care. She is also investigating the body’s immune response to cancer and new treatment approaches that combine standard therapies, such as surgery, radiation, and chemotherapy, with novel treatments such as immunotherapy.

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Charles Kooperberg , PhD

Email: clk@fredhutch.org

Phone: (206) 667-7808

Dr. Kooperberg's main research area is nonparametric function estimation and the analysis of high dimensional data, in particular as applied to genomic and proteomics data.

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Christopher Li , MD, PhD

Email: cili@fredhutch.org

Phone: (206) 667-7444

Dr. Li's research focuses on breast cancer and understanding factors related to its etiology and outcomes using a multidisciplinary approach. He studies the relationships between various hormonal exposures and risks of different types of breast cancer based on their morphology and expression of different tumor markers, risk factors for second primary breast cancer among breast cancer survivors, identifying markers that could be used for the early detection of different cancers using various proteomic platforms, examining disparities in cancer stage, treatment, and survival by race/ethnicity.

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Qinghang (Chris) Liu , PhD

Email: qcliu@uw.edu

Phone: (206) 685-9133

Dr. Liu's research is focused on defining novel signaling and transcriptional regulatory mechanisms that underlie cardiac hypertrophy and heart failure. In his lab, they take multi-disciplinary approaches including biochemistry, molecular and cell biology, molecular genetics, and system physiology to understand the molecular basis of heart disease using model systems ranging from yeast cell system to genetic mouse models.

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Yajuan Liu , PhD

Email: yajuan@uw.edu

Dr. Liu's research lab is currently focused on the following four projects: (1)Developing DNA sequence-based characterization of breakpoints of chromosome translocations/inversions in cancer using next generation sequencing. (2) Identifying new markers for Hepatitis C-associated hepatocellular carcinoma. (3) Correlating genetic alterations detected using genomic microarray and next generation sequencing with histology and clinical outcome in melanocytic neoplasms. (4) Use of genomic microarray analysis to rule in/out oncocytoma of the kidney in needle core biopsies. Dr. Liu's main goals are to identify cancer biomarkers and novel therapeutic targets and to develop molecular diagnostics using both conventional genetics methods and new genomic approaches to aid in precision diagnostics for personalized care.

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Georg Luebeck , PhD

Email: gluebeck@fredhutch.org

Phone: (206) 667-4282

Dr. Luebeck focuses primarily on the development of biomathematical descriptions of carcinogenesis, the identification and characterization of relevant spatio-temporal scales, and their impact on cancer incidence. The ultimate goal of his research is to being able to model/optimize the benefits of cancer screening, prevention, and intervention - based on a biological description of the natural history of cancer.

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Ryan Lynch , MD

Email: rclynch@uw.edu

Phone: (206) 606-1739

Dr. Lynch conducts clinical trials to optimize treatments and bring novel therapeutic agents to the clinic for patients with lymphomas and chronic lymphocytic leukemia.

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David MacPherson , PhD

Email: dmacpher@fredhutch.org

Phone: (206) 667-6464

Dr. MacPherson studies two tumor types, small cell lung carcinoma (SCLC) and retinoblastoma. He conducts genomic analyses of human tumors to identify gene mutations that may contribute to tumor initiation, progression and metastasis. His goal is to understand the mechanisms through which cancer-mutated genes drive tumorigenesis, small cell lung carcinoma (SCLC) and retinoblastoma.

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Harmit Malik , PhD

Email: hsmalik@fredhutch.org

Phone: (206) 667-5204

Dr. Malik is interested in a variety of problems that could all be classified under the genetics of evolutionary conflict. He studies rapidly evolving proteins as a hallmark of this kind of conflict, hoping to better understand the molecular nature of the conflict, as well as uncover previously unrecognized sources of conflict. His lab is currently working on several rapidly evolving projects including centromeres and heterochromatin, nuclear import and variant histones, and innate defense strategies against retroviruses

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Chris Miller , PhD

Email: cpmiller@u.washington.edu

Phone: (206) 543-3363

Dr. Miller works in Dr. Hootie Warren’s lab and is spearheading the development of a human microphysiological “tumor-on-a-chip” for accelerating investigation of the barriers to T cell immunotherapy in the solid tumor microenvironment, including the extracellular matrix and the vascular endothelium. Efforts are focused on the most common type of kidney cancer, renal cell carcinoma. Dr. Miller has experience developing the human 3D vascularized renal-cell-carcinoma-on-a-chip that faithfully recapitulates angiogenic blood vessel sprouting in the presence of patient tumor spheroids but not normal-adjacent kidney cells. The tumor-on-a-chip approach is broadly applicable to a variety of solid tumors.

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Ata Moshiri , MD, MPH

Email: amoshiri@uw.edu

Dr. Moshiri is the director of the T-VEC (talimogene laherparepvec) program at SCCA. With a background in cutaneous oncology and dermatopathology he is most interested in the genetic alterations that create and perpetuate cancer. Dr. Moshiri also has an interest in pigmented lesions and the use of non-invasive skin imaging to diagnose and monitor lesions.

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James (Jim) Mullins , PhD

Email: jmullins@u.washington.edu

Phone: (206) 732-6163

Dr. Mullins's lab uses the techniques of molecular, computational and virus biology to provide basic insights into the HIV-human host relationship in an effort to assist the fight to stop the AIDS pandemic. His team uses a variety of techniques to understand the implications of HIV's extraordinary genetic diversity for the pathogenesis of AIDS, with the intention of applying this information to the development of more effective therapies and vaccines. These techniques include virology; and molecular biological and statistical analysis of nucleotide sequences.

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Peter Nelson , MD

Email: pnelson@fredhutch.org

Phone: (206) 667-3377

Dr. Nelson is an oncologist specializing in therapies for early- and late-stage prostate cancer, pathology, and genome sciences. The focus of current work in the Nelson lab involves efforts to uncover how prostate cancer forms. The goal is to create tools to diagnose the onset of prostate cancer, develop prognostic strategies, and help develop more effective therapies for treating this disease.

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Yaw Nyame , MD

Email: nyamey@uw.edu

Phone: (206) 598-4294

Dr. Yaw Nyame has interest in healthcare disparities in urologic cancers, with interests both in the molecular, epigenomic and health services aspects of disparities outcomes in prostate cancer and other urologic malignancies.

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Patrick Paddison , PhD

Email: paddison@fredhutch.org

Phone: (206) 667-4312

Dr. Paddison's primary goal is to define the biological units of self-renewal, expansion, and lineage commitment in model stem cell systems, including: embryonic stem cells, hematopoietic stem cells, neural progenitor cells, and brain tumor initiating cells (i.e., brain tumor stem cells). His lab uses functional genomics to probe the underlying biology of mammalian stem and progenitor cells. Specifically, they are looking at glioblastoma as a model cancer system.

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