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q=Head%20 , %20Neck

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Walter Ruzzo , PhD

Email: ruzzo@cs.washington.edu

Phone: (206) 543-6298

Dr. Ruzzo's research is focused on development of computational methods and tools applicable to practical problems in molecular biology, an increasingly data-rich discipline. Recent work has focused on analysis of high throughput sequencing data, such as chromatin immunoprecipitation (ChIPseq) and transcriptomic (RNAseq) data, including development of new methods for mapping, assembly, bias correction, isoform quantitation, and motif discovery. New methods for finding noncoding RNA (ncRNA) genes are also being actively developed.

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Daniel Sabath , MD, PhD

Email: dsabath@uw.edu

Phone: (206) 897-5215

Dr. Sabath's main clinical research interest is the use of molecular techniques for the diagnosis of hematologic malignancies. His main research interest is regulation of gene expression in hematopoietic cells, with a long-term goal to determine the molecular mechanisms responsible for hematopoietic gene expression and how they become de-regulated in the setting of hematopoietic neoplasia.

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Rafael Santana-Davila , MD

Email: rafaelsd@u.washington.edu

Phone: (206) 288-2190

Dr. Rafael Santana-Davila is a medical oncologist who specializes in treating lung and head and neck cancers.

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Mark Schubert , DDS, MSD

Email: mschuber@seattlecca.org

Phone: (206) 288-1331

Dr. Schubert's current oncology research is focused on studies related to the prevention and management of oral mucositis associated with cancer therapy and medication-associated osteonecrosis of the jaw. His clinical expertise is in oral complications of cancer and therapy, oral infectious diseases, oral complications of HIV, antigens, and bone marrow transplantation. Dr. Schubert is also the Dental Director of the NW AIDS Education and Training Center.

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Stephen Schwartz , PhD

Email: sschwart@fredhutch.org

Phone: (206) 667-4660

Dr. Schwartz primarily studies the etiology and outcomes of cancer. A major objective of his research is to determine the influence of genetic susceptibility, either alone or in combination with lifestyle and environmental risk factors.

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Brian Shirts , MD, PhD

Email: shirtsb@uw.edu

Phone: (206) 598-0557

Dr. Shirt's research focuses on integrating complex genetics knowledge into clinical care. There are several related aspects of this research: clinical classification of rare variants, particularly variants in familial cancer genes; improving the use of complex and multi-factorial clinical information, with special interest in personalized healthcare using genetic information; and storage and communication of genetic information in the health care setting (including formatting genetic test results so that they are searchable in clinical laboratory information systems and so that electronic health records can use genetics to provide active decision support).

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Juila Sidorova , PhD

Email: julias@u.washington.edu

Phone: (206) 543-6585

Dr. Sidorova studies DNA replication in normal and cancer-derived human cells. She uses microfluidics assisted replication track analysis, or maRTA, a DNA fiber technology, to quantify genomic replication in vivo at the level of individual replication forks. Her lab’s specific interest is in the ways replication under stress generated by DNA damaging drugs or oncogenic mutations affects genomic stability and cell survival or promotes carcinogenesis.

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Lotte Steuten , PhD, MSc

Email: lsteuten@fredhutch.org

Phone: (206) 667-6956

Dr. Steuten's work focuses on the development and application of methods for early cycle health economic evaluation- conducted in the research and development phase - to help innovators focus on new treatments and medical technologies that are likely to be cost-effective, have the highest ROI and greatest impact on health.

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Roland Strong , PhD

Email: rstrong@fredhutch.org

Phone: (206) 667-5587

Dr. Strong's lab research focuses on structural molecular immunology and vaccinology by using biophysical approaches to study proteins and interactions mediating or modulating adaptive and innate immune responses.

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Wei Sun , Ph.D.

Email: wsun@fredhutch.org

Dr. Sun's research focuses on analyzing comprehensive genomic data, such as genome-wide DNA polymorphism (e.g., genotypes of thousands to millions of SNPs, DNA copy number variations), epigenetic information (e.g., nucleosome occupancy, histone modification), mRNA/miRNA expression, protein abundance/phosphorylation, and protein-protein interaction, as well as phenotype data to identify associations with complex traits, such as human cancer.

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Karen Syrjala , PhD

Email: ksyrjala@fredhutch.org

Phone: (206) 667-4579

Dr. Syrjala is Director of Behavioral Sciences and co-director of the Survivorship Program. Her focus is on helping people recognize their strengths and take charge of their health during treatment and long-term survival.

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Beverly Torok-Storb , PhD

Email: btorokst@fredhutch.org

Dr. Torok-Storb's work focuses on understanding how the cells of the bone marrow microenvironment regulate hematopoiesis.

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Yolanda Tseng , MD, M.Phil

Email: ydt2@uw.edu

Phone: (206) 598-4100

Dr. Tseng is a board-certified radiation oncologist with training and experience in proton radiotherapy, focusing on lymphoma, CNS, Merkel cell skin cancer, and palliative radiation. Her diverse research includes how physicians estimate patient prognosis and its effects on treatment decisions, and how tumor biological subtypes affect patient outcomes and the response to local therapy. She's interested in systematically evaluating how proton radiotherapy can be used to optimize patient care.

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Ruikang Wang , PhD

Email: wangrk@uw.edu

Phone: (206) 616-5025

Dr. Wang's research examines the behavior and properties of light and the interaction of light with biological tissues as a means to measure/image the properties of tissue, both morphological, functional and molecular, particularly the microvascular response.

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Edus (Hootie) Warren , MD, PhD

Email: ehwarren@fredhutch.org

Phone: (206) 667-6441

Dr. Warren's research focuses on the dissection of human antitumor immune responses at the cellular and molecular level. Dr. Warren is also medical oncologist specializing in leukemia and bone marrow transplant.

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Wei Wei , PhD

Email: wwei@systemsbiology.org

Phone: (206) 732-1221

The Wei group works in the highly cross-disciplinary field of BioMEMS, molecular and cellular analysis, and systems biomedicine. These joint efforts allow us to integrate single cell technologies with other biotechnological tools and computational approaches to investigate cutting-edge cancer biology questions with a balance between discovery and clinical translation. Specifically, we are interested in the following three areas: 1) Single-cell multi-omics tools and associated multivariate computational approaches for interrogating the heterogeneous tumor cells and immune cells at multiple bimolecular levels; 2) Epigenetic remodeling and signaling network dynamics associated with cell state transition and resistance development in epigenetically plastic tumors; 3) Liquid biopsy-based rare cell analysis for cancer metastasis and immunotherapy.

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Lue-Ping Zhao , PhD

Email: lzhao@fredhutch.org

Phone: (206) 667-6927

Being trained in biostatistics/bioinformatics, epidemiology and genetics, Dr. Zhao's current interest in STTR includes how to use omics methodology to dissect solid tumor etiology and mechanism with either expression arrays, SNP arrays, or short-read sequencing methods. Further, he is interested in utilizing large and complex electronic medical records with modern genomic technologies for translational bioinformatics studies.

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