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Nina Salama , PhD

Email: nsalama@fredhutch.org

Phone: (206) 667-1540

Dr. Salama's lab is interested in the mechanisms by which this bacterium can establish and maintain a chronic infection in the unusual environment of the human stomach and the molecular cross talk between the host and the bacteria during the decades long infection. The activation of host cell processes, either through direct action of bacterial products or as part of the host's attempt to contain the infection presumably causes the different diseases associated with H. pylori infection. To approach this complex problem, the lab is using both global and molecular approaches.

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Joshua Schiffer , MD, MS

Email: jschiffe@fredhutch.org

Phone: (206) 667-7359

Dr. Schiffer specializes in infectious diseases with particular interests in the management of HIV infected patients and other immunocompromised hosts. His current interests are in describing the quantitative and dynamical features of human pathogens and immune responses. Most of his work to-date is on the pathogenesis of HSV-2 infection but he also is interested in applying models to optimize viral eradication strategies, and in using models to capture kinetic features of the human microbiome.

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Stephen Schwartz , PhD

Email: sschwart@fredhutch.org

Phone: (206) 667-4660

Dr. Schwartz primarily studies the etiology and outcomes of cancer. A major objective of his research is to determine the influence of genetic susceptibility, either alone or in combination with lifestyle and environmental risk factors.

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Georg Seelig , PhD

Email: gseelig@u.washington.edu

Phone: (206) 616-3885

Dr. Seelig's lab investigates how synthetic biochemical systems can be designed to carry out algorithms and compute. In this research, Seelig developed DNA-based catalytic amplifiers and logic gates, demonstrating that DNA-based components can be modularly linked into multi-layered logic circuits that embody the main features of digital logic.

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Paul Shannon ,

Phone: (206) 732-1423

Shannon's goal in bioinformatics and computational biology is to use exploratory and confirmatory data analysis, upon inference, and upon modeling to eventually permit the prediction and control of complex biological systems. He believes network visualizations -- molecular maps -- created from an open-ended programming environment rich in statistical power and data-handling facilities, such as RCytoscape, will play an essential role in this progression.

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Eric Shea-Brown , PhD

Email: etsb@uw.edu

Phone: (206) 685-6635

Dr. Shea-Brown's interests span a wide set of topics in mathematical neuroscience and biological dynamics. Recent work focuses on optimal signal processing and decision making in simple neural networks, dynamics of neural populations in interval timing tasks, correlations and reliability in simple neural circuits, and properties of oscillator networks with generalized symmetries.

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Brian Shirts , MD, PhD

Email: shirtsb@uw.edu

Phone: (206) 598-0557

Dr. Shirt's research focuses on integrating complex genetics knowledge into clinical care. There are several related aspects of this research: clinical classification of rare variants, particularly variants in familial cancer genes; improving the use of complex and multi-factorial clinical information, with special interest in personalized healthcare using genetic information; and storage and communication of genetic information in the health care setting (including formatting genetic test results so that they are searchable in clinical laboratory information systems and so that electronic health records can use genetics to provide active decision support).

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Wenying Shou , PhD

Email: wenying.shou@gmail.com

Phone: (206) 667-6505

Dr. Shou's research is particularly interested in cooperative systems. Cooperation can be found virtually everywhere: between different cell types in our body, different individuals in an ant colony, and different species in a mutualistic interaction. Her lab plans to quantitatively study evolving biological systems using a combination of experimental biology and mathematical analysis.

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Emily Silgard , MS

Email: esilgard@fredhutch.org

Phone: (206) 667-4853

Emily Silgard's interests are in language processing for data extraction. She currently uses natural language processing to build a robust database for HIDRA based off of an extensive collection of clinical subjects. She is working closely with the different disease groups to interpret clinic and pathology reports to gather context, which informs and defines the pattern matching rules as well as knowledge based and statistical machine learning methods in her approach. Her future interests are to create a pipeline for computation and natural language processing.

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Gerald Smith , PhD

Email: gsmith@fredhutch.org

Phone: (206) 667-4438

Dr. Smith's research goals are to elucidate how recombination and DSB repair are accomplished and how they are regulated to occur at the proper place and time. His lab work is focused on meiotic recombination in the fission yeast Schizosaccharomyces pombe and on the major (RecBCD) pathway of recombination in the bacterium Escherichia coli. In both organisms he approaches this problem genetically, by analyzing mutants altered in the process, and biochemically, by studying the enzymes and special DNA sites (hotspots) that promote recombination and repair. These approaches are greatly facilitated by the advanced genetics and biochemistry of these microorganisms.

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Ntuthu Somdyala , PhD Fellow, Masters in Development Studies, BACur in Nursing Science, General Nurse & Midwife

Email: Nontuthuzelo.Somdyala@mrc.ac.za

Phone: +27 21 938 0954

Ntuthu Somdyala is a specialist in cancer surveillance, epidemiology, and prevention. She is integrally involved in the establishment and continued development of a population-based cancer registry in a rural Eastern Cape Province population of South Africa. The registry contributes to Cancer Incidence in Five Continents (CI5), which is published by WHO-International Agency for Research on Cancer (IARC). The registry is a full member of the IARC as well as the African Cancer Registry Network (AFCRN), participating in various collaborative studies through the network. The registry also collaborates with Eastern Cape Health Department to increase awareness about cancer and early detection with special emphasis on esophageal and cervical cancers. Capacity development and skills transfer is one of the major project-strengthening strategies of the registry team. Ms. Somdyala personally develops and mentors the registry team, including young Research Assistants.

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Janet Stanford , PhD

Email: jstanfor@fhcrc.org

Phone: (206) 667-2715

Dr. Stanford's research interests are in chronic disease epidemiology, specifically prostate cancer. She has worked on population-based case-control studies of risk factors (environmental, lifestyle, and genetic) for prostate cancer, studies of risk factors for prostate cancer recurrence/progression/mortality, studies of quality of life and function in prostate cancer survivors, and genetic susceptibility to sporadic and hereditary prostate cancer.

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Kari Stephens , PhD

Email: kstephen@uw.edu

Phone: (206) 221-0349

Dr. Stephens conducts research related to dissemination of evidenced base practices addressing mental health care and the leveraging of methods and tools focused on use of electronic health data to improve care. Her clinical expertise includes cognitive and behavioral based psychotherapy, including treatments for depression, anxiety, trauma, addiction, and chronic pain.

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Robert Stewart , PhD

Email: trawets@uw.edu

Phone: (206) 598-7951

Dr. Stewart's research is focused on biologically guided radiation therapy (BGRT), outcome assessment, and treatment individualization using biological metrics, such as the equivalent uniform dose (EUD) and biologically equivalent dose (BED) concepts.

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Roland Strong , PhD

Email: rstrong@fredhutch.org

Phone: (206) 667-5587

Dr. Strong's lab research focuses on structural molecular immunology and vaccinology by using biophysical approaches to study proteins and interactions mediating or modulating adaptive and innate immune responses.

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Stephen Tapscott , MD, PhD

Email: stapscot@fredhutch.org

Phone: (206) 667-4499

Dr. Tapscott's research focuses on the regulation of gene expression during the development of muscle and the nervous system and how this relates to cancers and degenerative diseases of brain and muscle. He has translational research programs in cell and gene therapy for muscular dystrophies and clinical studies to identify the mechanisms of facioscapulohumeral muscular dystrophy.

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Nancy Temkin , PhD

Email: temkin@uw.edu

Phone: (206) 616-6846

Dr. Temkin is a professor in neurological surgery an Biostatistics at the University of Washington whose research interests are in clinical trials, composite outcomes, survival analysis, translational research, and traumatic brain injury.

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Timothy Thornton , PhD

Email: tathornt@u.washington.edu

Phone: (206) 543-8004

Dr. Thornton's research interest is in the area of statistical genetics, with an emphasis on statistical methodology for case-control genome-wide association studies (GWAS) in samples with related individuals and/or hidden population structure.

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Toshio Tsukiyama , PhD, DVM

Email: ttsukiya@fredhutch.org

Phone: (206) 667-4996

Dr. Tsukiyama is interested in understanding how chromatin structure is regulated in vivo.

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Joseph Unger , PhD, MS

Email: junger@fredhutch.org

Phone: (206) 667-2860

Dr. Unger specializes and is interested in the design and analysis for quality of life; cancer prevention; symptom control; and comparative effectiveness studies.

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