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Christopher Li , MD, PhD

Email: cili@fredhutch.org

Phone: (206) 667-7444

Dr. Li's research focuses on breast cancer and understanding factors related to its etiology and outcomes using a multidisciplinary approach. He studies the relationships between various hormonal exposures and risks of different types of breast cancer based on their morphology and expression of different tumor markers, risk factors for second primary breast cancer among breast cancer survivors, identifying markers that could be used for the early detection of different cancers using various proteomic platforms, examining disparities in cancer stage, treatment, and survival by race/ethnicity.

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Shuying (Sue) Li , PhD

Email: sli@fredhutch.org

Phone: (206) 667-7066

Dr. Li is a senior scientist, whose research interests include development of genetic statistical methodologies, including phylogenetic tree reconstruction from genetic sequences, association of genetic markers with diseases, prediction of human leukocyte antigen (HLA) alleles from other polymorphisms such as single-nucleotide polymorphisms (SNPs), host genetics association with human immunity, especially immune-related diseases such as HIV infection and progression.

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Yawen Li , PhD

Email: liyw@uw.edu

Phone: (206) 616-8518

Dr. Li is interested in therapeutic and diagnostic radiopharmaceuticals, astatine labeling reagents for small molecule labeling, and developing chemical methods for separation of high specific activity medical radionuclides.

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Qinghang (Chris) Liu , PhD

Email: qcliu@uw.edu

Phone: (206) 685-9133

Dr. Liu's research is focused on defining novel signaling and transcriptional regulatory mechanisms that underlie cardiac hypertrophy and heart failure. In his lab, they take multi-disciplinary approaches including biochemistry, molecular and cell biology, molecular genetics, and system physiology to understand the molecular basis of heart disease using model systems ranging from yeast cell system to genetic mouse models.

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Yajuan Liu , PhD

Email: yajuan@uw.edu

Dr. Liu's research lab is currently focused on the following four projects: (1)Developing DNA sequence-based characterization of breakpoints of chromosome translocations/inversions in cancer using next generation sequencing. (2) Identifying new markers for Hepatitis C-associated hepatocellular carcinoma. (3) Correlating genetic alterations detected using genomic microarray and next generation sequencing with histology and clinical outcome in melanocytic neoplasms. (4) Use of genomic microarray analysis to rule in/out oncocytoma of the kidney in needle core biopsies. Dr. Liu's main goals are to identify cancer biomarkers and novel therapeutic targets and to develop molecular diagnostics using both conventional genetics methods and new genomic approaches to aid in precision diagnostics for personalized care.

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Georg Luebeck , PhD

Email: gluebeck@fredhutch.org

Phone: (206) 667-4282

Dr. Luebeck focuses primarily on the development of biomathematical descriptions of carcinogenesis, the identification and characterization of relevant spatio-temporal scales, and their impact on cancer incidence. The ultimate goal of his research is to being able to model/optimize the benefits of cancer screening, prevention, and intervention - based on a biological description of the natural history of cancer.

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Ryan Lynch , MD

Email: rclynch@uw.edu

Phone: (206) 606-1739

Dr. Lynch conducts clinical trials to optimize treatments and bring novel therapeutic agents to the clinic for patients with lymphomas and chronic lymphocytic leukemia.

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David MacPherson , PhD

Email: dmacpher@fredhutch.org

Phone: (206) 667-6464

Dr. MacPherson studies two tumor types, small cell lung carcinoma (SCLC) and retinoblastoma. He conducts genomic analyses of human tumors to identify gene mutations that may contribute to tumor initiation, progression and metastasis. His goal is to understand the mechanisms through which cancer-mutated genes drive tumorigenesis, small cell lung carcinoma (SCLC) and retinoblastoma.

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Julie McElrath , MD, PhD

Email: jmcelrat@fredhutch.org

Phone: (206) 667-6704

Dr. McElrath's lab investigates how components of T-cell immunity elicited early in HIV-1 infection contribute to control of HIV-1 disease, what the influence of antiretroviral therapy is, whether T-cell immune responses are involved in resistance to HIV-1 infection in high-risk persons, how antigen-specific mucosal T cells protect against HIV-1 exposure, and what elements of immunity correlate with protection against HIV-1 infection by vaccine.

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Chris Miller , PhD

Email: cpmiller@u.washington.edu

Phone: (206) 543-3363

Dr. Miller works in Dr. Hootie Warren’s lab and is spearheading the development of a human microphysiological “tumor-on-a-chip” for accelerating investigation of the barriers to T cell immunotherapy in the solid tumor microenvironment, including the extracellular matrix and the vascular endothelium. Efforts are focused on the most common type of kidney cancer, renal cell carcinoma. Dr. Miller has experience developing the human 3D vascularized renal-cell-carcinoma-on-a-chip that faithfully recapitulates angiogenic blood vessel sprouting in the presence of patient tumor spheroids but not normal-adjacent kidney cells. The tumor-on-a-chip approach is broadly applicable to a variety of solid tumors.

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Ata Moshiri , MD, MPH

Email: amoshiri@uw.edu

Dr. Moshiri is the director of the T-VEC (talimogene laherparepvec) program at SCCA. With a background in cutaneous oncology and dermatopathology he is most interested in the genetic alterations that create and perpetuate cancer. Dr. Moshiri also has an interest in pigmented lesions and the use of non-invasive skin imaging to diagnose and monitor lesions.

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Beth Mueller , DrPH

Email: bmueller@fredhutch.org

Phone: (206) 667-4903

Dr. Mueller studies the roles of maternal, gestational, and early life factors and early environmental exposures in the occurrence of childhood cancer and autoimmune diseases. Her studies include: reproductive history in relation to cancer and cancer survival in women; reproductive outcomes among male and female childhood cancer survivors; maternal, gestational, and early life factors and early environmental exposures in relation to reproductive outcomes such as malformations, fetal death, low birth weight, and preterm delivery; and improving exposure assessment methods in epidemiologic studies of prenatal and childhood exposures.

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James (Jim) Mullins , PhD

Email: jmullins@u.washington.edu

Phone: (206) 732-6163

Dr. Mullins's lab uses the techniques of molecular, computational and virus biology to provide basic insights into the HIV-human host relationship in an effort to assist the fight to stop the AIDS pandemic. His team uses a variety of techniques to understand the implications of HIV's extraordinary genetic diversity for the pathogenesis of AIDS, with the intention of applying this information to the development of more effective therapies and vaccines. These techniques include virology; and molecular biological and statistical analysis of nucleotide sequences.

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Viswam Nair , MD, MS

Email: vnair@fredhutch.org

Phone: (206) 667-4971

Dr. Viswam Nair translates fundamental scientific discoveries into the clinic to improve the care of people with lung cancer. His research focuses on biomarkers, or telltale biological markers of health or disease. He studies how to best integrate molecular and imaging-based biomarkers into clinical practice to improve lung cancer detection and treatment.

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Carolyn Nakisige , M.D.

Email: carolynnakisige@yahoo.com

Phone: +256-712659651

Carolyn Nakisige is interested in cervical cancer prevention and management in limited resource settings.

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Peter Nelson , MD

Email: pnelson@fredhutch.org

Phone: (206) 667-3377

Dr. Nelson is an oncologist specializing in therapies for early- and late-stage prostate cancer, pathology, and genome sciences. The focus of current work in the Nelson lab involves efforts to uncover how prostate cancer forms. The goal is to create tools to diagnose the onset of prostate cancer, develop prognostic strategies, and help develop more effective therapies for treating this disease.

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Yaw Nyame , MD

Email: nyamey@uw.edu

Phone: (206) 598-4294

Dr. Yaw Nyame has interest in healthcare disparities in urologic cancers, with interests both in the molecular, epigenomic and health services aspects of disparities outcomes in prostate cancer and other urologic malignancies.

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Kayode Ojo , PhD

Email: ojo67kk@uw.edu

Phone: (206) 543-0821

The research focus of the Ojo Lab is to develop novel, robust, safe and affordable antimicrobial agents that can withstand the threat of resistance while effectively treating debilitating parasitic diseases. They also have compounds in their drug library that could have an effect on breast, lung, melanoma and prostate cancer cells.

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Patrick Paddison , PhD

Email: paddison@fredhutch.org

Phone: (206) 667-4312

Dr. Paddison's primary goal is to define the biological units of self-renewal, expansion, and lineage commitment in model stem cell systems, including: embryonic stem cells, hematopoietic stem cells, neural progenitor cells, and brain tumor initiating cells (i.e., brain tumor stem cells). His lab uses functional genomics to probe the underlying biology of mammalian stem and progenitor cells. Specifically, they are looking at glioblastoma as a model cancer system.

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