Takuma Uo , Ph.D.
Email: tuo@uw.edu
Phone: 206-897-5463
Age is the most common risk factor for prostate cancer, with the rapid rise in its incidence after age 50. As a member of the prostate cancer research group in Division of Gerontology and Geriatric Medicine, Dr. Uo is focused on understanding molecular logics behind adaptive resistance of prostate cancer cells to the most forefront androgen-targeted therapies. Specifically, his research program examines the cell autonomous and nonautonomous mechanisms that enable prostate cancer progression, including the constitutively-active isoforms of androgen receptor, the metabolic rewiring, and the extracellular fuel supply from tumor microenvironment and adipose tissues. He harnesses in-depth knowledge and advanced technologies of molecular, cellular, chemical, synthetic, and computational biology to help develop next-generation of therapeutics to improve patient survival.
Roland B. Walter , MD, PhD
Email: rwalter@fredhutch.org
Phone: (206) 667-3599
Dr. Walter's research is focused on human acute myeloid leukemia (AML). He is particularly interested in the delineation of the clonal origin of AML, the molecular and phenotypic characterization of AML stem and progenitor cells, and the interaction between AML cells and their environment. An overarching goal of these studies is the development of targeted treatments aimed to eradicate disease-relevant AML cells, with CD33-directed therapies being one important specific example. He is also involved in the early testing of novel drugs and innovative care approaches in patients with AML. And he participates in collaborative projects utilizing large datasets that aim to improve diagnostic and prognostic tools in AML or, together with epidemiologists, study risk factors for the development of this hematological malignancy.
Ruikang Wang , PhD
Email: wangrk@uw.edu
Phone: (206) 616-5025
Dr. Wang's research examines the behavior and properties of light and the interaction of light with biological tissues as a means to measure/image the properties of tissue, both morphological, functional and molecular, particularly the microvascular response.
Edus (Hootie) Warren , MD, PhD
Email: ehwarren@fredhutch.org
Phone: (206) 667-6441
Dr. Warren's research focuses on the dissection of human antitumor immune responses at the cellular and molecular level. Dr. Warren is also medical oncologist specializing in leukemia and bone marrow transplant.
Bruce Weir , PhD
Email: bsweir@u.washington.edu
Phone: (206) 221-7947
Dr. Weir is chair and professor of the University of Washington department of biostatistics. He develops and applies statistical methods to genetic data. He also directs an NIGMS training grant in statistical genetics and he is very interested in the training of graduate students.
Noel Weiss , MD
Email: nweiss@uw.edu
Phone: (206) 685-1788
Dr. Weiss' research is primarily in the area of cancer epidemiology. Part of his time is devoted to the study of epidemiologic methods and of the application of these methods to the understanding of the determinants of the outcome of illness.
Paul Wiggins , PhD
Email: pwiggins@uw.edu
Phone: (626) 437-3761
Dr. Wiggins's research group focuses on achieving a greater understanding of how biological systems function and are structured at the microscopic scale. In particular, he is focused on Bacterial cell biology, chromosome structure and bacterial ultra-structure; quantitative Imaging; and DNA/membrane statistical mechanics.
Fei Xia , PhD, MS
Email: fxia@u.washington.edu
Phone: (206) 543-9764
Dr. Xia's research area is computational linguistics. Her research covers a wide range of NLP tasks including morphological analysis, part-of-speech tagging, grammar extraction and grammar generation, treebank development, machine translation, named-entity recognition, and information extraction.
Ka Yee Yeung , PhD
Email: kayee@uw.edu
Phone: (253) 692-4924
Dr. Yeung has extensive experience in the design of algorithms for the mining and integration of big data. She also has research expertise/interest spanning multiple disciplines, including computer science, statistics, computational biology, cancer biology and systems biology.
Cathy Yeung , PhD, PharmD
Email: cathyy@u.washington.edu
Phone: (206) 897-4709
Dr. Yeung's research includes both basic science and translational studies, and spans from the determination of molecular mechanisms of altered drug metabolism using 3-dimensional cell culture techniques to the evaluation of the effect of drugs and nutritional supplements on health outcomes in patients receiving hemodialysis. She is also involved in the development of a kidney on a chip microphysiological system that can be used in preclinical drug toxicity screening.
Lue-Ping Zhao , PhD
Email: lzhao@fredhutch.org
Phone: (206) 667-6927
Being trained in biostatistics/bioinformatics, epidemiology and genetics, Dr. Zhao's current interest in STTR includes how to use omics methodology to dissect solid tumor etiology and mechanism with either expression arrays, SNP arrays, or short-read sequencing methods. Further, he is interested in utilizing large and complex electronic medical records with modern genomic technologies for translational bioinformatics studies.