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Amy Paguirigan , PhD

Email: apaguiri@fredhutch.org

Phone: (206) 667-4352

The focus of my research has been the integration of emerging technologies to address clinically relevant questions in cancer biology. My focus is on the interface between clinical molecular biology, bioinformatics and biotechnology, in aiming to bridge the gaps to bring novel approaches in both the biotechnological and informatics realms to clinical molecular biology to study the role of clonal diversity in cancer therapy.

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Amanda Paulovich , MD, PhD

Email: apaulovi@fredhutch.org

Phone: (206) 667-1912

Dr. Paulovich is a medical oncologist by training whose research focuses on the study of human phenotypic variation. Her projects include, the development of high throughput, multiplexed technologies for targeted protein quantification in blood, plasma and solid tissues and their use to determine human phenotypic variation in the cellular response to DNA damage, and to elucidate the network of genes and pathways that buffer defects in this response.

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Thomas Payne , MD

Email: tpayne@uw.edu

Dr. Payne’s major professional interest is the use and evaluation of clinical computing systems, especially electronic health records (EHRs) in patient care, clinical research, and quality improvement. Most of his work since completing his fellowship has involved development, selection, installation and operation of EHRs. His research interests include electronic documentation, natural language processing, and operating clinical computing programs.

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Steve Perlmutter , PhD

Email: perl@uw.edu

Phone: (206) 616-8520

Dr. Perlmutter's research work is relevant to clinical issues of motor impairment and recovery of function following central nervous system damage. Abnormal patterns of muscle activation following brain and spinal cord injury contribute to weakness and loss of coordination. His research will advance the understanding of the capacity for adaptation, and suggest ways to exploit this potential for improved function.

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Ulrike Peters , PhD, MPH

Email: upeters@fredhutch.org

Phone: (206) 667-2450

Dr. Peter's research interests center on the genetic and molecular epidemiology of common complex diseases, including cancer, obesity, type 2 diabetes, and stroke, as well as intermediate traits, including inflammation, glucose, or insulin. She is studying the impact of common and rare genetic variants across the entire genome, as well as interactions between genetic variants and environmental factors (such as diet, exercise, smoking, aspiring use).

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Hong Qian , PhD

Email: qian@amath.washington.edu

Phone: (206) 543-2584

Dr. Qian's main research interest is the mathematical approach to and physical understanding of biological systems, especially in terms of stochastic mathematics and nonequilibrium statistical physics. In recent years, he has been particularly interested in a nonlinear, stochastic, open system approach to cellular dynamics. Similar population dynamic approach can be applied to other complex systems and processes, such as those in ecology, infection epidemics, and economics. He believes his recent work on the statistical thermodynamic laws of general Markov processes can have applications in economic dynamics and theory of values.

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Jerry Radich , MD

Email: jradich@fredhutch.org

Phone: (206) 667-4118

Dr. Radich's lab team is studying the molecular genetics of response, progression, and relapse in human leukemia. These studies rely on a close interaction of his lab to clinical research performed at the Center, as well as collaborations with large clinical trials of the Southwest Oncology Group

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Daniel Raftery , PhD

Email: draftery@uw.edu

Phone: (206) 543-9709

Dr. Raftery is an expert in the field of metabolomics, the study of small molecules involved in the metabolism of biological systems, cells, animals and humans. His research focuses on the development of advanced analytical tools and statistical methodologies for profiling metabolites in complex biological samples. He has applied these analytic approaches and demonstrated their utility for early detection of several types of cancer, as well as their utility in researching diabetes and heart disease.

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Scott Ramsey , MD, PhD

Email: sramsey@fredhutch.org

Phone: (206) 667-7846

Dr. Ramsey is a member of the Public Health Sciences Division at Fred Hutch. His research focus is comparative effectiveness analysis; cost effectiveness analysis, health economics, and cancer outcomes research. He is a doctors and health economists who has lead studies on patterns of care, costs and cost-effectiveness of treatments for lung, colorectal and prostate cancer.

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Timothy Randolph , PhD

Email: trandolp@fredhutch.org

Phone: (206) 667-1079

Dr. Randolph's current research focuses on processing, classification and analysis of high-dimensional and/or functional data output from protein mass spectrometry, genetic assays and a variety of spectroscopies and imaging modalities. His other interests include methods for the analysis of networks used to describe gene and/or protein interactions.

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Wendy Raskind , MD, PhD

Email: wendyrun@u.washington.edu

Phone: (206) 543-3177

Dr. Raskind's current research seeks to identify and study genes responsible for neurobehavioral disorders. Her lab investigates a variety of Mendelian neurogenetic disorders, including spastic paraplegia, movement disorders, and ataxias, in a large family set collected over more than 3 decades. Raskind's team uses multiple gene localization techniques combined with exome sequencing and bioinformatics to identify candidate genes responsible for the disease. In addition, the Raskind Lab study the genetics of dyslexia and familial Alzheimers disease. They are using a combination of linkage analysis and genomic sequencing to identify genes that contribute to the risk of developing these common and heterogeneous disorders.

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Mary Redman , PhD

Email: mredman@fredhutch.org

Phone: (206) 667-4767

Dr. Redman's primary interests are in clinical trial designs for assessment and discovery of predictive biomarkers of targeted agents and interim monitoring considerations for hybrid designs.

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Thomas Richardson , MD, FACC

Email: thomasr@uw.edu

Phone: (206) 685-8488

Dr. Richardson's main area of research, graphical models, has developed at the interface between statistics and computer science, but has origins and applications in econometrics, epidemiology, genomics, psychology, and sociology. In other words, graphs (composed of vertices and edges) provide a language for formulating complex hypotheses.

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Harlan Robins , PhD

Email: hrobins@fredhutch.org

Phone: (206) 667-2571

Dr. Robins's research is computationally based and focuses on the adaptive immune system and its response to viral infection, with HIV a particular area of interest. Taking advantage of new high-throughput sequencing technology, in collaboration with experimental groups, we are isolating and sequencing millions of t-cell receptor VDJ rearrangements from different clonotypes.

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Walter Ruzzo , PhD

Email: ruzzo@cs.washington.edu

Phone: (206) 543-6298

Dr. Ruzzo's research is focused on development of computational methods and tools applicable to practical problems in molecular biology, an increasingly data-rich discipline. Recent work has focused on analysis of high throughput sequencing data, such as chromatin immunoprecipitation (ChIPseq) and transcriptomic (RNAseq) data, including development of new methods for mapping, assembly, bias correction, isoform quantitation, and motif discovery. New methods for finding noncoding RNA (ncRNA) genes are also being actively developed.

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Nina Salama , PhD

Email: nsalama@fredhutch.org

Phone: (206) 667-1540

Dr. Salama's lab is interested in the mechanisms by which this bacterium can establish and maintain a chronic infection in the unusual environment of the human stomach and the molecular cross talk between the host and the bacteria during the decades long infection. The activation of host cell processes, either through direct action of bacterial products or as part of the host's attempt to contain the infection presumably causes the different diseases associated with H. pylori infection. To approach this complex problem, the lab is using both global and molecular approaches.

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George Sandison , PhD

Email: sandison@u.washington.edu

Dr. Sandison's research is focused on radiation transport theory for dose and RBE computation and radiation therapy motion management and quantitative imaging analysis.

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Joshua Schiffer , MD, MS

Email: jschiffe@fredhutch.org

Phone: (206) 667-7359

Dr. Schiffer specializes in infectious diseases with particular interests in the management of HIV infected patients and other immunocompromised hosts. His current interests are in describing the quantitative and dynamical features of human pathogens and immune responses. Most of his work to-date is on the pathogenesis of HSV-2 infection but he also is interested in applying models to optimize viral eradication strategies, and in using models to capture kinetic features of the human microbiome.

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Frank Schmitz , MD, PhD

Email: fschmitz@fredhutch.org

Dr. Schmitz is the Director of Translational and Molecular Medicine for the Chapuis Lab at Fred Hutch. He is working on a personalized anti-tumor vaccine approach, building off previous work in innate immunity and vaccine formulation during his postdocs.

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