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Stephen Schwartz , PhD

Email: sschwart@fredhutch.org

Phone: (206) 667-4660

Dr. Schwartz primarily studies the etiology and outcomes of cancer. A major objective of his research is to determine the influence of genetic susceptibility, either alone or in combination with lifestyle and environmental risk factors.

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Parth Shah , PharmD, PhD

Email: pshah@fredhutch.org

Phone: (206) 667-6120

Dr. Parth Shah is a behavioral scientist and pharmacist who integrates these two disciplines to study and improve clinical practice and health policy in the delivery of cancer care. His research focuses on how pharmacies can be better used to provide cancer prevention and care services to their communities, such as HPV vaccinations for adolescents and colorectal cancer screenings for adults. Additional research interests also include medical and end-of-life decision-making and improving palliative care.

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Tao Sheng Kwan-Gett , MD, MPH

Email: kwangett@u.washington.edu

Phone: (206) 685-8140

Dr. Sheng Kwan-Gett's current interests are public health practice; communicable disease epidemiology; health informatics.

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Min Shi , PhD

Email: mshi70@uw.edu

Phone: (206) 897-5707

Dr. Shi has a broad background and specific expertise in protein engineering, gene expression regulation, and signal transduction in disease settings. At the University of Washington School of Medicine, Dr. Shi has expanded his research to include proteomics-based discovery and targeted validation of candidate proteins in in vitro models. He has also led or was critically involved in projects to apply the proteomic-based discoveries, and other important proteins, as biomarkers for neurodegenerative disorders such as Parkinson disease and Alzheimer disease.

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Brian Shirts , MD, PhD

Email: shirtsb@uw.edu

Phone: (206) 598-0557

Dr. Shirt's research focuses on integrating complex genetics knowledge into clinical care. There are several related aspects of this research: clinical classification of rare variants, particularly variants in familial cancer genes; improving the use of complex and multi-factorial clinical information, with special interest in personalized healthcare using genetic information; and storage and communication of genetic information in the health care setting (including formatting genetic test results so that they are searchable in clinical laboratory information systems and so that electronic health records can use genetics to provide active decision support).

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Wenying Shou , PhD

Email: wenying.shou@gmail.com

Phone: (206) 667-6505

Dr. Shou's research is particularly interested in cooperative systems. Cooperation can be found virtually everywhere: between different cell types in our body, different individuals in an ant colony, and different species in a mutualistic interaction. Her lab plans to quantitatively study evolving biological systems using a combination of experimental biology and mathematical analysis.

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Emily Silgard , MS

Email: esilgard@fredhutch.org

Phone: (206) 667-4853

Emily Silgard's interests are in language processing for data extraction. She currently uses natural language processing to build a robust database for HIDRA based off of an extensive collection of clinical subjects. She is working closely with the different disease groups to interpret clinic and pathology reports to gather context, which informs and defines the pattern matching rules as well as knowledge based and statistical machine learning methods in her approach. Her future interests are to create a pipeline for computation and natural language processing.

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Christopher D. Simpson , PhD, MS

Email: simpson1@u.washington.edu

Phone: (206) 543-3222

Dr. Simpson's research interests involve the application of analytical chemistry to the development of techniques for assessment of exposure to toxic chemicals, and the subsequent application of those techniques to investigate occupational and environmental exposures. He is particularly interested in the development of analytical methodology to measure xenobiotics and their metabolites or transformation products in biological samples (biomarkers). In support of these efforts, Simpson conducts studies to develop sampling and analysis methods for environmental samples, to provide accurate external exposure measures to validate the biomarkers. He is also interested in applying biomarker techniques in the field of chemical carcinogenesis to provide new insights into the role of metabolic phenotype and environmental factors in modifying cancer risk.

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Ka'imi Sinclair , PhD, MPH

Email: kaimi.sinclair@wsu.edu

Phone: (206) 708-8633

Dr. Sinclair has a specific background in culturally tailored interventions and educational materials for diverse tribal groups. Her current research focuses on eliminating cardiometabolic disparities of diabetes, obesity, and cardiovascular disease through intervention and epidemiology.

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Gerald Smith , PhD

Email: gsmith@fredhutch.org

Phone: (206) 667-4438

Dr. Smith's research goals are to elucidate how recombination and DSB repair are accomplished and how they are regulated to occur at the proper place and time. His lab work is focused on meiotic recombination in the fission yeast Schizosaccharomyces pombe and on the major (RecBCD) pathway of recombination in the bacterium Escherichia coli. In both organisms he approaches this problem genetically, by analyzing mutants altered in the process, and biochemically, by studying the enzymes and special DNA sites (hotspots) that promote recombination and repair. These approaches are greatly facilitated by the advanced genetics and biochemistry of these microorganisms.

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Ntuthu Somdyala , PhD Fellow, Masters in Development Studies, BACur in Nursing Science, General Nurse & Midwife

Email: Nontuthuzelo.Somdyala@mrc.ac.za

Phone: +27 21 938 0954

Ntuthu Somdyala is a specialist in cancer surveillance, epidemiology, and prevention. She is integrally involved in the establishment and continued development of a population-based cancer registry in a rural Eastern Cape Province population of South Africa. The registry contributes to Cancer Incidence in Five Continents (CI5), which is published by WHO-International Agency for Research on Cancer (IARC). The registry is a full member of the IARC as well as the African Cancer Registry Network (AFCRN), participating in various collaborative studies through the network. The registry also collaborates with Eastern Cape Health Department to increase awareness about cancer and early detection with special emphasis on esophageal and cervical cancers. Capacity development and skills transfer is one of the major project-strengthening strategies of the registry team. Ms. Somdyala personally develops and mentors the registry team, including young Research Assistants.

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Leonidas Stamatatos , PhD

Email: lstamata@fredhutch.org

Phone: (206) 667-2995

Dr. Stamatatos research is focused on better understanding how neutralizing antibodies against HIV are developed during natural HIV-infection, in a subset of individuals infected with HIV. His lab's main interests are identifying immunologival pathways that lead to the development of broadly neutralizing antibodies during HIV infection and exploit these pathways for vaccine-related purposes. They also focus on understanding how the HIV virus evolves to avoid the action of such antibodies.

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Janet Stanford , PhD

Email: jstanfor@fhcrc.org

Phone: (206) 667-2715

Dr. Stanford's research interests are in chronic disease epidemiology, specifically prostate cancer. She has worked on population-based case-control studies of risk factors (environmental, lifestyle, and genetic) for prostate cancer, studies of risk factors for prostate cancer recurrence/progression/mortality, studies of quality of life and function in prostate cancer survivors, and genetic susceptibility to sporadic and hereditary prostate cancer.

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Kari Stephens , PhD

Email: kstephen@uw.edu

Phone: (206) 221-0349

Dr. Stephens conducts research related to dissemination of evidenced base practices addressing mental health care and the leveraging of methods and tools focused on use of electronic health data to improve care. Her clinical expertise includes cognitive and behavioral based psychotherapy, including treatments for depression, anxiety, trauma, addiction, and chronic pain.

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Robert Stewart , PhD

Email: trawets@uw.edu

Phone: (206) 598-7951

Dr. Stewart's research is focused on biologically guided radiation therapy (BGRT), outcome assessment, and treatment individualization using biological metrics, such as the equivalent uniform dose (EUD) and biologically equivalent dose (BED) concepts.

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Roland Strong , PhD

Email: rstrong@fredhutch.org

Phone: (206) 667-5587

Dr. Strong's lab research focuses on structural molecular immunology and vaccinology by using biophysical approaches to study proteins and interactions mediating or modulating adaptive and innate immune responses.

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Lucas Sullivan , PhD

Email: lucas@fredhutch.org

Phone: (206) 667-7826

Dr. Lucas Sullivan studies cell metabolism under normal and cancerous conditions. He also aims to deepen the understanding of metabolism in general, working to discover new molecular products of metabolism and their roles in sustaining cell survival and growth. The current goals of the lab seek to span from translationally relevant projects, testing metabolism modifying therapies in preclinical cancer models, to basic science discovery, investigating new roles for coenzyme networks and identifying new metabolites, to better understand cell metabolism in cancer and beyond.

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Billie Swalla , PhD

Email: bjswalla@u.washington.edu

Phone: (206) 616-9367

Dr. Swalla's goal is to understand the evolution of the chordate body plan, a complex problem that requires interdisciplinary research. As vertebrates, humans are chordates, but there are also several groups of invertebrate chordates that her team study for clues to our evolution. The lab combine methods and approaches in phylogenetics, development, ecology and evolution to study the evolution of the chordate body plan from a deuterostome ancestor.

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Stephen Tapscott , MD, PhD

Email: stapscot@fredhutch.org

Phone: (206) 667-4499

Dr. Tapscott's research focuses on the regulation of gene expression during the development of muscle and the nervous system and how this relates to cancers and degenerative diseases of brain and muscle. He has translational research programs in cell and gene therapy for muscular dystrophies and clinical studies to identify the mechanisms of facioscapulohumeral muscular dystrophy.

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