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Niels Andersen , PhD

Email: andersen@chem.washington.edu

Phone: (206) 543-7099

Dr. Anderson's research team focuses on both the fundamental thermodynamics and structural features associated with biorecognition phenomena and practical applications in drug and protein design. The primary biophysical tools employed are spectroscopic: NMR determinations of polypeptide structure and dynamics, IR- and fluorescence-monitored T-jump kinetics for folding pathways, CD studies of the melting of secondary and tertiary structure. His drug design efforts are supported by NMR structural data for protein hormones and enzymes for key steps required for the viability of bacteria.

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Mike Averkiou , PhD

Email: maverk@uw.edu

Phone: (206) 616-9558

Dr. Averkiou develops new ultrasound imaging and therapy technology for disease detection, improved cancer treatment and monitoring, improved drug delivery to targeted cells, and heart disease. Using advanced nonlinear imaging techniques and microbubble contrast agents, he is able to detect the earliest stages of tumor angiogenesis and atherosclerosis, and closely monitor their treatment. He focuses on transferring innovations from preclinical research into clinical use.

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James (Jim) Bassingthwaighte , MD, PhD

Email: jbb2@uw.edu

Phone: (206) 685-2012

Dr. Bassingthwaighte's lab uses multiple radioactive tracers simultaneously to measure reactions of adenosine and its metabolites and to determine their rates of transport across membranes. Models describe the kinetics in a precise way, allowing us to understand the regulation. He is also the originator of the Human Physiome Project, a large-scale international program for developing databasing and biological systems modeling for understanding genomic and pharmaceutic effects on human physiology. His program is highly collaborative, involving co-investigators at a dozen U.S. universities, several in Europe, and in 14 departments at the University of Washington. Some of these are involved in the Physiome Project, in particular the Cardiome Project. The Cardiome Project, to define a functional heart in mathematical terms, extends from the biochemistry and the signaling, to the mechanics and energetics of the three-dimensional heart.

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Karl Bohringer , PhD

Email: karlb@u.washington.edu

Phone: (206) 221-5177

Dr. Bohringer's current research interests include micromanipulation and microassembly, as well as biomedical implants and bioMEMS for single-cell genomics and proteomics. There are two major research themes in his work: Controlling surfaces and interfacial forces at the micro and nano scale, including systems for controlled self-assembly of microcomponents, programmable surfaces whose local properties (for example, hydrophobicity) can be changed on demand, and MEMS actuator arrays and microrobots for moving tiny objects; Joining MEMS and biology by integrating new biomaterials into MEMS processes and devices, biomedical sensor implants, and microfluidic chips for handling and analyzing biological samples. Dr. Bohringer is also interested in discussing ideas for leveraging the unique capabilities of the Washington Nanofabrication Facility for research programs in the biomedical field.

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Karol Bomsztyk , MD

Email: karolb@uw.edu

Phone: (206) 616-7949

Dr. Bomstyzk areas of research interest include pathogenesis of bacterial, fungal and parasitic diseases; epigenetics of inflammation and infection; and epigenetics of HIV infection.

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Roger Brent , PhD

Email: rbrent@fredhutch.org

Phone: (206) 667-1482

Dr. Brent studies the quantitative operation of the systems that living cells use to sense, represent, transmit, and act upon information to make decisions that determine their future fates. He specifically studies prototypic cell signaling systems in budding yeast and the pheromone response system; he has extended similar work to systems operating in single cells of tissues in a metazoan, Caenorhabditis elegans.

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Elizabeth Buffalo , PhD

Email: ebuffalo@uw.edu

Phone: (206) 543-1432

Dr. Buffalo's general research focus is to contribute to a better understanding of the neural mechanisms involved in learning and memory. She uses neurophysiological techniques to record information, simultaneously, from multiple electrodes in the hippocampus and surrounding cortex in awake, behaving monkeys. She investigates how changes in neuronal activity correlate with the monkey's ability to learn and remember, and she's particularly interested in the activity of neuronal networks that underlie learning and memory processes.

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Cole DeForest , PhD

Email: ProfCole@uw.edu

Phone: (206) 543-5961

The DeForest Group seeks to integrate the governing principles of rational design with fundamental concepts from material science, synthetic chemistry, and stem cell biology to conceptualize, create, and exploit next-generation materials to address a variety of health-related problems. They are currently interested in the development of new classes of user-programmable hydrogels whose biochemical and biophysical properties can be tuned in time and space over a variety of scales. Their work relies heavily on the utilization of cytocompatible bioorthogonal chemistries, several of which can be initiated with light and thereby confined to specific sub-volumes of a sample. By recapitulating the dynamic nature of the native tissue through 4D control of the material properties, these synthetic environments are utilized to probe and better understand basic cell function as well as to engineer complex heterogeneous tissue.

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Zhijun Duan , PhD

Email: zjduan@uw.edu

Phone: (206) 543-3363

Dr. Duan's research is focused on the relationship between the form and function of human genomes during development and tumorigenesis. One of the striking features of the eukaryotic nucleus is that chromosomes adopt preferred conformations that vary across different tissues and developmental stages.

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Leroy (Lee) Hood , MD, PhD

Email: lhood@systemsbiology.org

Phone: (206) 732-1200

The Hood group is integrating biology, technology and computation to create a predictive, personalized, preventive and participatory approach to medicine. His projects center on cancer biology of prostate, glioblastoma and lung cancers, systems approach to prion disease in glioblastoma mouse models, new strategies for obtaining blood biomarkers, and a systems approach to diagnosis and stratification of disease.

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Eric Klavins , PhD

Email: klavins@ee.washington.edu

Phone: (206) 616-1743

Dr. Klavins is an associate professor of electrical engineering at the University of Washington in Seattle. He holds adjunct appointments in Computer Science and Engineering and in Bioengineering and is the Director for the UW Center for Synthetic Biology. Until approximately 2008, Klavins' research was primarily in computer science and control systems, focusing on stochastic processes, robotics and self-assembly. At about this time, he learned the basics of genetic engineering of the next few years switched entirely fields to synthetic biology and now runs an interdisplinary group of engineers, biologists, experimentalists, and theorists -- all focused on engineering life. His current projects include synthetic multicellular systems with engineered bacteria and yeast, modeling and design for synthetic multicellular systems, and laboratory automation.

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Jonathan (Jon) Liu , PhD, MS

Email: jonliu@uw.edu

Phone: (206) 543-5339

Dr. Liu's work focuses on developing optical strategies for biomedical diagnostics and therapy. These endeavors require multi-disciplinary advances in optical devices, contrast agents, image processing, and preclinical/clinical studies. For example, over the past few years, our lab has published on the simulation and development of a miniaturized advanced volumetric microscopy technology to enable real-time point-of-care pathology, as well as the development of molecularly targeted contrast agents to guide the surgical resection of tumors. These complementary technologies have the potential to revolutionize patient care by providing surgeons with a real-time alternative to invasive biopsy and frozen-sectioning pathology for confirming the status of tissues at the final stages of surgery. In addition, our lab is developing spectral imaging devices in conjunction with multiplexed Raman nanoparticles for the endoscopic visualization of large panels of disease biomarkers. This technology for the rapid molecular phenotyping of tissues has the potential to improve the early detection and surgical treatment of cancers, as well as to guide personalized therapies.

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Steve Perlmutter , PhD

Email: perl@uw.edu

Phone: (206) 616-8520

Dr. Perlmutter's research work is relevant to clinical issues of motor impairment and recovery of function following central nervous system damage. Abnormal patterns of muscle activation following brain and spinal cord injury contribute to weakness and loss of coordination. His research will advance the understanding of the capacity for adaptation, and suggest ways to exploit this potential for improved function.

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Hong Qian , PhD

Email: qian@amath.washington.edu

Phone: (206) 543-2584

Dr. Qian's main research interest is the mathematical approach to and physical understanding of biological systems, especially in terms of stochastic mathematics and nonequilibrium statistical physics. In recent years, he has been particularly interested in a nonlinear, stochastic, open system approach to cellular dynamics. Similar population dynamic approach can be applied to other complex systems and processes, such as those in ecology, infection epidemics, and economics. He believes his recent work on the statistical thermodynamic laws of general Markov processes can have applications in economic dynamics and theory of values.

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Jay Rubinstein , MD, PhD

Email: rubinj@u.washington.edu

Phone: (206) 616-6655

Dr. Rubinstein has published over 110 peer reviewed articles in both clinical and basic science journals and has mentored 18 predoctoral and postdoctoral trainees in basic and translational research, as well as, providing clinical training to a large number of otolaryngology residents and fellows. His laboratory studies models of signal processing in and perception with cochlear implants and is collaborating in the development of a vestibular implant. Rubinstein's clinical interests encompass management of tumors of the lateral skull base, as well as, auditory, vestibular and facial nerve disorders

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George Sandison , PhD

Email: sandison@u.washington.edu

Dr. Sandison's research is focused on radiation transport theory for dose and RBE computation and radiation therapy motion management and quantitative imaging analysis.

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Georg Seelig , PhD

Email: gseelig@u.washington.edu

Phone: (206) 616-3885

Dr. Seelig's lab investigates how synthetic biochemical systems can be designed to carry out algorithms and compute. In this research, Seelig developed DNA-based catalytic amplifiers and logic gates, demonstrating that DNA-based components can be modularly linked into multi-layered logic circuits that embody the main features of digital logic.

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Matthias Stephan , MD, PhD

Email: mstephan@fredhutch.org

Phone: (206) 667-6677

The main goal of Dr. Stephan's research is to explore the fast-developing and highly interdisciplinary field of immunobioengineering. Using next-generation immunomodulatory synthetic materials, his team is developing new approaches to therapeutically boost the body's natural ability to fight cancer. His team's primary research focuses include the design of stimulatory biomaterial devices, drug delivery systems and bioactive substances to enhance adoptive immunotherapy for cancer.

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Barry Stoddard , PhD

Email: bstoddar@fredhutch.org

Phone: (206) 667-4031

Dr. Stoddard's lab focuses on to understanding the structure/function relationships of several interesting biological systems at the atomic level. The tools employed by his team are X-ray crystallography, computer modelling, and genetic manipulation of the molecules of interest

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Ruikang Wang , PhD

Email: wangrk@uw.edu

Phone: (206) 616-5025

Dr. Wang's research examines the behavior and properties of light and the interaction of light with biological tissues as a means to measure/image the properties of tissue, both morphological, functional and molecular, particularly the microvascular response.

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