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Jennifer Adair , PhD

Email: jadair@fredhutch.org

Phone: (206) 667-7110

Dr. Adair's laboratory aims to develop gene therapies that can correct faulty DNA sequences responsible for inherited blood disorders, improve treatment for brain cancer and make cells immune to HIV infection. In addition to her independent work, Adair collaborates with the Kiem Lab to move new gene therapies created in the lab into clinical trials.

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Eun Hyun Ahn , PhD

Email: ahneun@uw.edu

Dr. Ahn’s current research interests are focused on: Breast cancer stem cell mutagenesis and DNA repair and microenvironmental regulation of cancer stem cells and carcinogenesis. Dr.Ahn’s previous research areas include: (1) Identification and biochemical characterization of target genes of PAX3-FOXO1 in alveolar rhabdomyosarcoma; (2) Regulation of differentiation of human mesenchymal stem cells and cardiac precursor cells by nanotopography-induced cellular stiffness and rigidity; (3) Roles of retinoic acids and retinoic acid receptorson proliferation, cell cycle, and cell signaling; (4) chemotherapeutic and chemopreventive mechanisms of sphingolipids in colon and breast cancers; Anti-tumorigenic activities of antisense oligonucleotides against AKT1 in various cancer cells.

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Jalal Andre , MD

Email: drjalal@uw.edu

Phone: (206) 598-8766

Dr. Andre has specific training and experience in the development and clinical implementation of emerging MRI technologies. Dr. Andre's most recent interests include the application of advanced MRI techniques in imaging traumatic brain injury. His research has also led to identification of features that can be used in the evaluation of high-risk medulloblastoma subtypes.

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Yoshimi Anzai , MD, MPH

Email: anzai@u.washington.edu

Phone: (206) 598-8188

Dr. Yoshimi is the Professor of Radiology at University of Washington. Dr. Anzai utilizes various neuroimaging equipment and techniques to diagnose neurological diseases present in the nervous system, head, neck and spine. Her research interests include, hypoxia imaging using metabolic and vascular uncoupling for head and neck cancer, Multicenter trial AC RIN 6685 for head and neck cancer for N0 neck, evaluation of brain iron deposition in Parkinson Disease and Traumatic Brain Injury, and imaging assessment of cochlear implants.In addition, she conducts health services research in radiology, such as how imaging effects treatment decisions, patient outcomes/wellness, or overall costs in various diseases in cancer or neurodegenerative diseases.

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Geoffrey Baird , MD, PhD

Email: gbaird@uw.edu

Phone: (206)744-9787

Dr. Baird's clinical interests include laboratory test utilization, molecular diagnostics, proteomics and immunohistochemistry. His group has developed a new proteomic technology for biomarker discovery in a range of diseases such as malignancies, cardiovascular disorders, and inflammatory conditions. One application of their technology is to discover protein expression changes associated with non-small cell lung cancer that have implications for diagnosis and treatment.

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K. Scott Baker , MD

Email: ksbaker@fredhutch.org

Phone: (206) 667-5594

Dr. Baker is a pediatric oncologist. His main focus is on late effects of cancer therapy, in particular in patients that have undergone hematopoietic stem cell transplant for non-malignant disorders such as bone marrow failure syndromes, primary immunodeficiencies, and the histocytic disorders. He is interested in the use of umbilical cord blood for use in transplantation for both malignant and non-malignant diseases.

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Nitin Baliga , PhD

Email: nbaliga@systemsbiology.org

Phone: (206) 732-1266

Dr. Baliga leads a group which builds predictive models of complex biological phenomena that can be used to guide cells in the fight against disease, they have established numerous collaborations to apply this methodology to wide-ranging problems from climate change to cancer. In ongoing research, Dr. Baliga is applying advanced methods to the study of brain cancer (glioblastoma multiforme) to gain insights into human disease to improve prevention, diagnosis, prognosis and treatment.

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Norman Beauchamp , MD, MHS

Email: nbeauch@u.washington.edu

Phone: (206) 543-0871

Beauchamp's area of clinical expertise is neuroradiology and neurointerventional radiology. His research interests include: using imaging to non-invasively obtain the correct diagnosis and to assess effectiveness of treatment, using imaging to identify risk predictors of stroke and dementia; developing and validating diagnostic tools for the early diagnosis of acute stroke; applying interventions to minimize injury secondary to stroke. He also has a patent for the computer-aided processing and analysis for stroke in neuroimages.

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Kathleen Bell , MD

Email: krbell@u.washington.edu

Phone: (206) 685-0935

Dr. Bell's area of interest and expertise has always been neuro-rehabilitation. Her clinical interests include traumatic brain injury (behavior management, headaches, sleep disorders, outcome), stroke, brain tumors and medically complex patients. Her research areas are: self management techniques for persons with brain injury, exercise and depression after brain injury, and headache and sleep disorders after brain injury.

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Parveen Bhatti , PhD

Email: pbhatti@fredhutch.org

Phone: (206) 667-7803

Dr. Bhatti's research focus is on occupational and environmental epidemiology of cancer with a focus in biomarkers of exposure, susceptibility and disease; particularly genetic susceptibility to cancer following low dose exposure to occupational or medical ionizing radiation.

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Mark Binder , PhD

Email: mdbinder@uw.edu

Phone: (206) 543-2509

Dr. Binder's lab is presently investigating the dendritic mechanisms affecting the transfer of synaptic current to the soma of hypoglossal motoneurons recorded in rat brainstem slices. His team studies the voltage-dependance of the synaptic currents, what types of voltage-gated conductances on the dendrites affect the transfer of current to the soma and how concurrently-activated synaptic currents interact. They also use fluorescent imaging to determine the spatial distribution of the dendritic sodium, calcium, and mixed-cation channels. Binder's experimental projects are complemented by computer simulations using compartmental models of motoneurons with different types and distributions of dendritic conductances to help interpret the experimental data.

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Jesse Bledsoe , PhD

Email: bledsoe1@washington.edu

Dr. Bledsoe studies brain-behavior relationships in pediatric brain tumors, neuroimaging, neuropsychology.

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Hamid Bolouri , PhD

Email: hbolouri@fredhutch.org

Phone: (206) 667-2748

Dr. Bolouri is interested in understanding how gene regulatory interactions control cellular state and identity, both in normal development and in diseases such as cancer. A particular focus of his lab is the development and use of integrative computational systems biology methods to map gene regulatory networks from whole genome data: currently they are working on identification of cis-regulatory sequence variations in childhood Acute Myeloid Leukemia.

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Mark Bothwell , PhD

Email: mab@uw.edu

Phone: (206) 543-7924

Dr. Bothwell's research interest is the regulatory function of growth factors in the developing nervous system during embryonic development. Moreover, he is interested in the functions of growth factors in the adult nervous system, in the processes of memory and learning, in the repair of nervous system injury, in neurodegenerative conditions and also their role in tumor biology.

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Robert Bradley , PhD

Email: rbradley@fredhutch.org

Phone: (206) 667-5662

Dr. Bradley uses genomics, sequence analysis, and molecular genetics to study the mechanistic origins and phenotypic consequences of alternative splicing and other RNA processing. He wants to identify diseases where RNA processing plays important, and previously unrecognized, roles. His laboratory studies pre-neoplastic diseases and cancers such as brain, prostrate and breast cancer.

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Roger Brent , PhD

Email: rbrent@fredhutch.org

Phone: (206) 667-1482

Dr. Brent studies the quantitative operation of the systems that living cells use to sense, represent, transmit, and act upon information to make decisions that determine their future fates. He specifically studies prototypic cell signaling systems in budding yeast and the pheromone response system; he has extended similar work to systems operating in single cells of tissues in a metazoan, Caenorhabditis elegans.

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James (Jim) Brinkley , MD, PhD

Email: brinkley@u.washington.edu

Phone: (206) 543-3954

Dr. Brinkley's primary research interest is biomedical informatics - the representation, management, sharing, visualization and utilization of neuroscience data and knowledge. He is the founder of the field of Structural Informatics, which has as its goal the development of methods for representing the structure of the body at multiple levels of detail, as for using these methods for organizing and integrating biomedical information. His aim is to find ways to represent the structure or the body in computer-readable form, and find ways to associate these representations with the myriad biomedical data that are available. His goal is to provide a structural information framework for integrating a huge variety of big and small biomedical data. Dr. Brinkley's projects have included anatomy education, brain mapping through the national Human Brain Project, cardiovascular data integration, clinical trials data integration through the national Clinical translational Science Awards, radiological image annotation and integration through the RadLex project, and craniofacial malformations data integration through the national FaceBase consortium. He is also interested in developing web-accessible computer applications utilizing these representations to solve practical problems in clinical medicine, research and education.

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Samuel Robert Browd , MD, PhD

Email: sbrowd@u.washington.edu

Phone: (206) 987-4240

Dr. Browd's specialties are with children who have hydrocephalus, brain & spinal cord tumors, pediatric cervical spine, spina bifida, chiari malformations, spasticity. His research interests include complex, high resolution medical imaging including Functional Neuro Imaging; clinical trials and patient outcome; craniopagus twins; cervical spine issues related to down syndrome.

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Jonathan Cooper , PhD

Email: jcooper@fredhutch.org

Phone: (206) 667-4454

Dr. Cooper studies signaling events that control the architecture of the developing brain. Dr. Cooper is an expert in the signaling pathways that allow cells to communicate with each other and affect the behavior of normal and cancer cells. In particular, his group is interested in studying the Src protein family to understand how they regulate normal cell behavior and their transformation to cancer cells. More recent studies from his laboratory have revealed a mechanism that coordinates cell migrations during brain development and uses many of the same genes and proteins that are important in cancer.

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Courtney Crane , PhD

Email: courtney.crane@seattlechildrens.org

Phone: (206) 884-4084

Dr. Crane's major area of interest is in the identification of novel targets for cellular immunotherapies for patients with malignant brain tumors. Crane's team is unraveling exactly how cancer cells disarm immune cells, with the goal of finding ways to reprogram those immune cells so they can elude cancers defenses and destroy brain tumors, neuroblastoma and other cancers.

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