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James Dai , PhD

Email: jdai@fredhutch.org

Phone: (206) 667-6364

James Dai’s Lab works in statistical genetics and genomics, design and analysis of randomized clinical trials, statistical methods for high-dimensional feature selection and prediction, gene-treatment interaction, mediation and instrumental variables regression. Methodologically, his lab is also interested in cancer genomics topics, for example integrative genomic analyses and intra-tumor heterogeneity. The overarching scientific interest is to discover and validate and genomic markers that drive cancer etiology, predict cancer prognosis and treatment efficacy.

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Heather Gustafson , PhD

Email: heather.gustafson@seattlechildrens.org

Phone: (206) 884-7339

Dr. Gustafson's career has focused on harnessing existing and developing novel technology platforms that alter macrophage function through environmental manipulation. Her current research, involves engineering several macrophage phenotype targeting methods in order to understand these interactions. Her lab does this through the development of technology platforms that target specific macrophage phenotypes and alter macrophage phenotypes for therapeutic and diagnostic applications. Through the development and use of these technologies they can develop and understanding of how environmental cues impact macrophage function, how macrophage function drives disease progression and how to harness that information to engineer novel technologies to treat disease.

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Amy Paguirigan , PhD

Email: apaguiri@fredhutch.org

Phone: (206) 667-4352

The focus of my research has been the integration of emerging technologies to address clinically relevant questions in cancer biology. My focus is on the interface between clinical molecular biology, bioinformatics and biotechnology, in aiming to bridge the gaps to bring novel approaches in both the biotechnological and informatics realms to clinical molecular biology to study the role of clonal diversity in cancer therapy.

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Rosana Risques , PhD

Email: rrisques@uw.edu

Phone: (206) 543-5337

Dr. Risques' research interest is the study of the genetic mechanisms that lead to tumor progression and its translation into potential biomarkers for early cancer detection. Her studies focus in ulcerative colitis, an inflammatory bowel disease that predisposes to colorectal cancer. Prior studies demonstrated that telomere shortening, mitochondrial alterations, and clonal expansions are involved in neoplastic progression in this disease. Her current efforts are dedicated to translate these molecular alterations into cancer biomarkers using novel technologies such as NanoString and new approaches to Next-Gen Sequencing.

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Scott Tykodi , MD, PhD

Email: stykodi@fredhutch.org

Phone: (206) 606-7763

Dr. Tykodi treats patients with kidney cancer and melanoma. He is particularly interested in the application of immune therapies to the treatment of cancer. His research focus is in the clinical application and translational study of natural or induced T-cell immunity targeting renal cell carcinoma and other cancers.

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