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q=Colorectal

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Smith (Jim) Apisarnthanarax , MD

Email: apisarn@uw.edu

Phone: (206) 598-4100

Dr. Apisarnthanarax is a radiation oncologist with clinical expertise in gastrointestinal cancers and genitourinary tumors, including the use of proton radiation to treat these cancers. Dr. Apisarnthanarax's research interests include optimizing the treatment of liver cancers, integrating proton beam radiation therapy into the multidisciplinary care of cancer, and using novel functional imaging to personalize cancer care by decreasing normal tissue toxicity and assessing cancer treatment response.

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Justin Ashworth , PhD

Email: Justin.Ashworth@systemsbiology.org

Phone: (206) 732-2179

Dr. Ashworth is interested in the modeling and prediction of molecular and genetic variations in cellular systems, and the ways in which the functions and interactions of proteins are "designed" in nature to yield cellular physiologies and adaptations. Recently I have been studying gene regulation of new microorganisms and the functional roles of mutations in cellular systems in order to relate our biophysical understanding of molecular function and evolution to systems-level characteristics.

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Anthony Back , MD

Email: tonyback@u.washington.edu

Phone: (206) 288-6426

Dr. Back is a medical oncologist who specializes in treating cancers of the gastrointestinal system. Dr. Back also treats patients at SCCA. His patients include people with colorectal, liver, pancreatic, and stomach cancer. He is an expert in communication between physicians and patients and has published a number of papers on this topic.

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Geoffrey Baird , MD, PhD

Email: gbaird@uw.edu

Phone: (206)744-9787

Dr. Baird's clinical interests include laboratory test utilization, molecular diagnostics, proteomics and immunohistochemistry. His group has developed a new proteomic technology for biomarker discovery in a range of diseases such as malignancies, cardiovascular disorders, and inflammatory conditions. One application of their technology is to discover protein expression changes associated with non-small cell lung cancer that have implications for diagnosis and treatment.

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Laura Mae Baldwin , MD, MPH

Email: lmb@u.washington.edu

Phone: (206) 685-4799

Dr. Baldwin is a health services researcher with a focus on access to and quality of health care in diverse underserved and rural areas. Her areas of interest are cancer prevention and treatment, and perinatal health, all with an eye towards ensuring equitable access to high quality health services across U.S.

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Shirley Beresford , PhD, MSc, MA

Email: beresfrd@u.washington.edu

Phone: (206) 543-9512

Dr. Beresford's research interests are in the areas of nutritional epidemiology and chronic disease prevention; specifically designed to improve the scientific basis for public health policy and recommendations concerning dietary intake, physical activity and intake of folic acid.

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Jason Bielas , PhD

Email: jbielas@fredhutch.org

Dr. Bielas leads a group group studies the fundamental and clinical implications of nuclear and mitochondrial DNA mutations in the pathogenesis of cancer and age-related disease including breast and ovarian cancer. Recently, his laboratory has developed a new test for predicting ovarian cancer survival.

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C. Anthony (Tony) Blau , MD

Email: tblau@u.washington.edu

Phone: (206) 685-6873

Dr. Blau specializes in orchestrating collaborations across disparate scientific disciplines toward grand goals. As a physician-scientist he believes that our approach to cancer needs to be fundamentally restructured, and for this reason founded the UW's Center for Cancer Innovation (CCI). CCI applies the latest scientific knowledge to the treatment of today's cancer patients while using their experiences to benefit all cancer patients tomorrow. CCI recently launched its first clinical trial in an aggressive form of breast cancer called 'triple-negative' breast cancer. CCI is a grass-roots 'coalition of the willing,' comprised of nearly 100 community and academic oncologists, scientists, computational biologists, and other specialists from six different organizations, and owes much of its success to support from the South Sound region.

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Lynn Bonham , PhD

Email: lbonham@seattlecca.org

Phone: (206)288-2022

Dr. Bonham directs and manages Cellular Therapeutics at SCCA, which processes cells from peripheral blood, bone marrow and cord blood for standard transplantations and clinical trials for cancer treatment.

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Ivana Bozic , PhD

Email: ibozic@uw.edu

Phone: (206) 543-5077

Dr. Bozic studies the evolution of cancer and its resistance to treatment through mathematical and computational modeling. Her interests lie in both theoretical aspects of these models and their application. On the theoretical side, Bozic studies stochastic processes, especially multi-type branching processes, and their finite time characteristics. Dr. Bozic collaborates extensively with experimental and clinical researchers to integrate modeling with clinical data, providing insight into the natural history of cancer in vivo.

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Roger Brent , PhD

Email: rbrent@fredhutch.org

Phone: (206) 667-1482

Dr. Brent studies the quantitative operation of the systems that living cells use to sense, represent, transmit, and act upon information to make decisions that determine their future fates. He specifically studies prototypic cell signaling systems in budding yeast and the pheromone response system; he has extended similar work to systems operating in single cells of tissues in a metazoan, Caenorhabditis elegans.

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Teresa Brentnall , MD

Email: teribr@u.washington.edu

Phone: (206) 897-1821

Dr. Brentnall research interest is in understanding tumorigenesis in the gastrointestinal tract with emphasis in: molecular events and early detection of pancreatic cancer; surveillance and management of patients who inherit pancreatic cancer; molecular events, prevention, and early detection of colon cancer in patients with inflammatory bowel disease.

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James (Jim) Brinkley , MD, PhD

Email: brinkley@u.washington.edu

Phone: (206) 543-3954

Dr. Brinkley's primary research interest is biomedical informatics - the representation, management, sharing, visualization and utilization of neuroscience data and knowledge. He is the founder of the field of Structural Informatics, which has as its goal the development of methods for representing the structure of the body at multiple levels of detail, as for using these methods for organizing and integrating biomedical information. His aim is to find ways to represent the structure or the body in computer-readable form, and find ways to associate these representations with the myriad biomedical data that are available. His goal is to provide a structural information framework for integrating a huge variety of big and small biomedical data. Dr. Brinkley's projects have included anatomy education, brain mapping through the national Human Brain Project, cardiovascular data integration, clinical trials data integration through the national Clinical translational Science Awards, radiological image annotation and integration through the RadLex project, and craniofacial malformations data integration through the national FaceBase consortium. He is also interested in developing web-accessible computer applications utilizing these representations to solve practical problems in clinical medicine, research and education.

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David Byrd , MD

Email: byrd@u.washington.edu

Phone: (206) 543-7512

Dr. Byrd’s clinical interests are in the areas of surgical oncology, endocrine neoplasms (thyroid, parathyroid, adrenal), gastrointestinal and pancreatic cancers, breast cancer, melanoma. His research interests are to study the molecular changes in pancreatic cancer, genetic and clinical studies on melanoma, and lymphatic mapping in breast cancer and melanoma. He is an expert in many surgical procedures, including the Whipple procedure used in pancreas cancer treatment.

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Christopher Carlson , PhD

Email: ccarlson@fredhutch.org

Phone: (206) 667-7034

Dr. Carlson's research focus is the identification and functional dissection of polymorphisms that correlate with common diseases and quantitative traits; assessing the functional impact of candidate SNPs on a variety of regulatory mechanisms, including promoter function and mRNA structure. Currently he is also involved in high throughput sequencing of the rearranged TCR and BCR repertoire for adaptive immune system profiling in cancer and performing functional analysis of genome wide associations in colorectal cancer.

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Krishnavel Chathadi , MD

Email: kchathadi@medicine.washington.edu

Phone: (206) 598-4377

Dr. Chathadi is a gastroenterologist and he cares for patients with esophageal cancer. His clinical and research interests are Pancreaticobiliary Endoscopy including Diagnostic and Interventional Endoscopic Ultrasound and Cholangiopancreatoscopy with Electrohydraulic and Laser Lithotripsy; Advanced Therapeutic Endoscopy including Endoscopic Mucosal resection; Endoluminal Stenting and Extracorporeal Shock Wave Lithotripsy; Quality of care.

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Mac Cheever , MD

Email: mcheever@fredhutch.org

Phone: (206) 667-4141

Dr. Cheever's specialty is in the areas of medical oncology, immunotherapy and solid tumor research. His current research interests are in conducting cancer clinical trials to develop and test new immunotherapies. He also interested on developing the principles of T cell therapy, cancer antigen discovery and development of cancer vaccines, especially for breast cancer.

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Ru Chen , PhD

Email: ruc@medicine.washington.edu

Phone: (206) 221-4109

Dr. Ru Chen's research area centers focuses on two aspects: the discovery of protein biomarkers for early detection of pancreatic cancer; and the study of the molecular mechanisms underlying pancreatic tumorigenesis. In addition, her research area also includes other GI diseases, such as IBD and related colon cancer.

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Monique Cherrier , PhD

Email: cherrier@u.washington.edu

Phone: (206) 277-3594

Dr. Cherrier specializes in neuropsychology with a special interest in behavioral medicine, geriatrics, dementias and related disorders, and cancer and cancer-related cognitive dysfunction and rehabilitation. Currently she is examining the impact of cognitive training for cancer survivors, including neuroimaging.

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Yong Chi , PhD

Email: ychi@fredhutch.org

Phone: (206) 667-5255

Currently, Dr. Chi is a staff scientist in the laboratory of Dr. Bruce Clurman in the Clinical Research Division of the Fred Hutch and is also affiliated with the laboratory of Dr. Robert Moritz at ISB. He has been developing proteomics-based tools to facilitate biological research. Specifically, he has pursued a proteomics approach to systematically identify the direct substrates of protein kinases. Mapping kinase and substrate relationships is critical for elucidating kinases functions and their signaling pathways. Despite the enormous interests and efforts in the field, it has remained a technical challenge, and the progress has been slow. He developed an in vitro-based method for proteome-wide identification of protein kinase substrates in cell lysates. This method utilized tools in biology, protein chemistry, and mass spectrometry and identified an unprecedented large number of candidate substrates for the human CDK2 kinase. Current in vitro and in vivo approaches suffer the shortcoming of large false-positive identifications due to non-physiological settings or indirect hits. He is now working on a cell-based approach that would minimize false-positive identifications due to the non-physiological settings while maintaining direct kinase-substrate relationships.

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