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Shreeram Akilesh , MD, PhD

Email: shreeram@uw.edu

Phone: (206) 598-6408

Dr. Akilesh is presently applying next generation genomic tools and analyses to understand the development, structure and function of the kidney and its component cells in health and disease.

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Niels Andersen , PhD

Email: andersen@chem.washington.edu

Phone: (206) 543-7099

Dr. Anderson's research team focuses on both the fundamental thermodynamics and structural features associated with biorecognition phenomena and practical applications in drug and protein design. The primary biophysical tools employed are spectroscopic: NMR determinations of polypeptide structure and dynamics, IR- and fluorescence-monitored T-jump kinetics for folding pathways, CD studies of the melting of secondary and tertiary structure. His drug design efforts are supported by NMR structural data for protein hormones and enzymes for key steps required for the viability of bacteria.

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Steve Andrews , PhD

Email: sandrews@fredhutch.org

Phone: (206) 667-7007

Dr. Andrews's research is in the interdisciplinary field of systems biology. His interests are in the combination of physics, chemistry, and biology methods to investigate organization within biological systems, on size scales that typically range from a few proteins to many cells. Results are yielding insights into how the highly structured macroscopic world of living organisms is built from the stochastic microscopic world of individual molecules. He is also providing an improved conceptual foundation for medical and biotechnology developments, with impacts on topics such as drug discovery, personalized medicine, biofuel generation, and bioremediation.

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Wyeth Bair , PhD

Email: wyeth0@uw.edu

Phone: (206) 221-8241

Dr. Bair's group integrates computational modeling and electrophysiology to study neural coding and cortical circuitry in the visual system. A primary focus of his work is the visual motion pathway. He is currently developing several integrated online resources to carry out his goals. These include the Neural Signal Archive, which contains neuronal data for public access; the Working Models site, which provides access to network models of the visual system; and the data system, which is a set of utilities for storing and analyzing spike trains.

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Geoffrey Baird , MD, PhD

Email: gbaird@uw.edu

Phone: (206)744-9787

Dr. Baird's clinical interests include laboratory test utilization, molecular diagnostics, proteomics and immunohistochemistry. His group has developed a new proteomic technology for biomarker discovery in a range of diseases such as malignancies, cardiovascular disorders, and inflammatory conditions. One application of their technology is to discover protein expression changes associated with non-small cell lung cancer that have implications for diagnosis and treatment.

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Nitin Baliga , PhD

Email: nbaliga@systemsbiology.org

Phone: (206) 732-1266

Dr. Baliga leads a group which builds predictive models of complex biological phenomena that can be used to guide cells in the fight against disease, they have established numerous collaborations to apply this methodology to wide-ranging problems from climate change to cancer. In ongoing research, Dr. Baliga is applying advanced methods to the study of brain cancer (glioblastoma multiforme) to gain insights into human disease to improve prevention, diagnosis, prognosis and treatment.

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Brittany Barber , MD, MSc, FRCSC

Email: bbarber1@uw.edu

Dr. Barber's clinical interests include head and neck cancer surgery, robotic surgery, and salivary and endocrine surgery. She has a special interest in reconstructive surgery for skin cancers. Her research interests include quality improvement in free flap reconstruction, peripheral nerve regeneration, cancer genomics, and HPV-related oropharyngeal cancer treatment.

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Kevin Barry , PhD

Email: kbarry@fredhutch.org

Phone: (206) 667-7811

Dr. Barry aims to determine how innate immune cells recognize cancer and regulate immune responses. He previously identified a novel set of immune cells that regulate immune responses that protect patients from melanoma. The number of these cells in a patient’s tumor can identify those patients who will benefit the most from immunotherapy. Dr. Barry and his team are learning more about the signals that control this set of innate immune cells in cancer. His goal is to generate novel therapies to increase cancer-killing immune responses and save lives from cancer.

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Shirley Beresford , PhD, MSc, MA

Email: beresfrd@u.washington.edu

Phone: (206) 543-9512

Dr. Beresford's research interests are in the areas of nutritional epidemiology and chronic disease prevention; specifically designed to improve the scientific basis for public health policy and recommendations concerning dietary intake, physical activity and intake of folic acid.

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Slobodan Beronja , PhD

Email: beronja@fredhutch.org

Phone: (206) 667-7609

Dr. Beronja's group studies molecular and cellular mechanisms essential for tissue growth during development and the formation of tumors. His goal is to identifying genes and gene pathways that can be used as targets in cancer therapy.

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Parveen Bhatti , PhD

Email: pbhatti@fredhutch.org

Phone: (206) 667-7803

Dr. Bhatti's research focus is on occupational and environmental epidemiology of cancer with a focus in biomarkers of exposure, susceptibility and disease; particularly genetic susceptibility to cancer following low dose exposure to occupational or medical ionizing radiation.

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Karl Bohringer , PhD

Email: karlb@u.washington.edu

Phone: (206) 221-5177

Dr. Bohringer's current research interests include micromanipulation and microassembly, as well as biomedical implants and bioMEMS for single-cell genomics and proteomics. There are two major research themes in his work: Controlling surfaces and interfacial forces at the micro and nano scale, including systems for controlled self-assembly of microcomponents, programmable surfaces whose local properties (for example, hydrophobicity) can be changed on demand, and MEMS actuator arrays and microrobots for moving tiny objects; Joining MEMS and biology by integrating new biomaterials into MEMS processes and devices, biomedical sensor implants, and microfluidic chips for handling and analyzing biological samples. Dr. Bohringer is also interested in discussing ideas for leveraging the unique capabilities of the Washington Nanofabrication Facility for research programs in the biomedical field.

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Hamid Bolouri , PhD

Email: hbolouri@fredhutch.org

Phone: (206) 667-2748

Dr. Bolouri is interested in understanding how gene regulatory interactions control cellular state and identity, both in normal development and in diseases such as cancer. A particular focus of his lab is the development and use of integrative computational systems biology methods to map gene regulatory networks from whole genome data: currently they are working on identification of cis-regulatory sequence variations in childhood Acute Myeloid Leukemia.

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Karol Bomsztyk , MD

Email: karolb@uw.edu

Phone: (206) 616-7949

Dr. Bomstyzk areas of research interest include pathogenesis of bacterial, fungal and parasitic diseases; epigenetics of inflammation and infection; and epigenetics of HIV infection.

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Stephen Bowen , PhD

Email: srbowen@uw.edu

Phone: (206) 598-1128

Dr. Bowen's research focuses on quantitative molecular imaging of cancer and normal tissue for personalized radiation therapy. Specifically he is interested in machine learning of respiratory patterns for personalized motion management strategies during image acquisition, radiotherapy planning, and radiotherapy delivery; dose painting based on respiratory-gated FDG PET in NSCLC; and functional avoidance planning of both MAA and DTPA SPECT-defined lung regions in NSCLC and SC SPECT-defined liver regions in HCC.

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Roger Brent , PhD

Email: rbrent@fredhutch.org

Phone: (206) 667-1482

Dr. Brent studies the quantitative operation of the systems that living cells use to sense, represent, transmit, and act upon information to make decisions that determine their future fates. He specifically studies prototypic cell signaling systems in budding yeast and the pheromone response system; he has extended similar work to systems operating in single cells of tissues in a metazoan, Caenorhabditis elegans.

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Susan Bullman , PhD

Email: sbullman@fredhutch.org

Phone: (206) 667-3449

The Bullman Lab focuses firstly on understanding the translational impact of the tumor microbiota in human cancers, and secondly on the delineation of specific mechanisms involved in the pathogenesis of microbe-associated human cancers. They combine molecular microbiology, computational biology, biochemistry, and genetics to understand host-microbial interactions within the tumor microenvironment. Through such efforts, her lab seeks to make discoveries that have both a scientific and clinical impact in the emerging area of bacterial-associated malignancies. Bacterial agents that have a role in cancer initiation or progression provide a viable route for prevention and treatment of these cancers.

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Chu Chen , PhD, NRCC, DABCC

Email: cchen@fredhutch.org

Phone: (206) 667-6644

Dr. Chen's research interests include the identification of 1) diagnostic and prognostic markers to aid personalized management of head and neck cancer based on gene expression profiles, loss of heterozygosity, DNA copy number, and tissue microarray data.; and 2) determinants for the susceptibility to and survival from cancers of the head and neck, lung, endometrium, breast, prostate and testes through investigations into lifestyle factors, endogenous and environmental exposures, and genetic and epigenetic influences.

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Victor Chow , MD

Email: vchow@fredhutch.org

Phone: (206) 667-7731

Dr. Chow conducts clinical research in lymphoma utilizing combination approaches with cellular-based therapies.

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James Dai , PhD

Email: jdai@fredhutch.org

Phone: (206) 667-6364

James Dai’s Lab works in statistical genetics and genomics, design and analysis of randomized clinical trials, statistical methods for high-dimensional feature selection and prediction, gene-treatment interaction, mediation and instrumental variables regression. Methodologically, his lab is also interested in cancer genomics topics, for example integrative genomic analyses and intra-tumor heterogeneity. The overarching scientific interest is to discover and validate and genomic markers that drive cancer etiology, predict cancer prognosis and treatment efficacy.

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