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Jennifer Adair , PhD

Email: jadair@fredhutch.org

Phone: (206) 667-7110

Dr. Adair's laboratory aims to develop gene therapies that can correct faulty DNA sequences responsible for inherited blood disorders, improve treatment for brain cancer and make cells immune to HIV infection. In addition to her independent work, Adair collaborates with the Kiem Lab to move new gene therapies created in the lab into clinical trials.

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Erica Anderson-Nissen , PhD

Email: eanderse@fhcrc.org

Phone: +27 (0)21 202 2228

Dr. Andersen-Nissen is interested in studying the influence of early innate immune responses to HIV vaccines on subsequent adaptive immune responses elicited. In addition, she studies systems biology analyses of how immune responses are shaped.

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Wyeth Bair , PhD

Email: wyeth0@uw.edu

Phone: (206) 221-8241

Dr. Bair's group integrates computational modeling and electrophysiology to study neural coding and cortical circuitry in the visual system. A primary focus of his work is the visual motion pathway. He is currently developing several integrated online resources to carry out his goals. These include the Neural Signal Archive, which contains neuronal data for public access; the Working Models site, which provides access to network models of the visual system; and the data system, which is a set of utilities for storing and analyzing spike trains.

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Ruanne Barnabas , MBChB, DPhil

Email: rbarnaba@uw.edu

Phone: 206 520-3813

Dr. Barnabas is an Infectious Disease Physician-Scientist at the University of Washington and affiliate at the Fred Hutchinson Cancer Research Center. Her research focuses on HIV treatment and prevention, specifically on interventions that reduce HIV viral load and, consequently, disease progression and transmission. Her projects use both empiric data and mathematical models to better understand HIV clinical progression and transmission, and estimate the potential impact of HIV interventions at population level. The ultimate aim of her work is to estimate the effectiveness and cost-effectiveness of HIV treatment and prevention interventions to inform clinical trial design.

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Karol Bomsztyk , MD

Email: karolb@uw.edu

Phone: (206) 616-7949

Dr. Bomstyzk areas of research interest include pathogenesis of bacterial, fungal and parasitic diseases; epigenetics of inflammation and infection; and epigenetics of HIV infection.

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James Dai , PhD

Email: jdai@fredhutch.org

Phone: (206) 667-6364

James Dai’s Lab works in statistical genetics and genomics, design and analysis of randomized clinical trials, statistical methods for high-dimensional feature selection and prediction, gene-treatment interaction, mediation and instrumental variables regression. Methodologically, his lab is also interested in cancer genomics topics, for example integrative genomic analyses and intra-tumor heterogeneity. The overarching scientific interest is to discover and validate and genomic markers that drive cancer etiology, predict cancer prognosis and treatment efficacy.

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Stephen DeRosa , MD

Email: sderosa@fredhutch.org

Phone: (206) 667-1681

Dr. DeRosa's research focuses on the flow cytometric characterization of T cells induced by candidate T cell vaccines tested within the HIV Vaccine Trials Network (HVTN). HIs lab has developed assays that examine multiple T cell markers and functions simultaneously. An ultimate goal of his research is to identify the characteristic features of effective immune responses. Recent studies in his laboratory related to the failure of the vaccines tested in the Step trial have resulted in a broader examination of the potential impact of vaccinations on the immune system. Dr. DeRosa is examining T cells that are specific for the vaccine vector. His team is also developing methods to identify regulatory or suppressive T cells that can potentially be induced by vaccination.

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Deborah Donnell , PhD

Email: deborah@scharp.org

Phone: (206) 667-5661

Dr. Donnell is a Principal Staff Scientist in the Vaccine and Infectious Disease Institute (VIDI). She is the Principal Investigator of the HIV Prevention Trials Network Statistical and Data Management Center. The scientific faculty, drawing from the University of Washington Biostatistics department and the Population Sciences Program in VIDI, are responsible for the design and analysis of Phase III clinical trials to access the efficacy of biomedical and behavioral interventions to prevent the transmission of HIV

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Michael Emerman , PhD

Email: memerman@fredhutch.org

Phone: (206) 667-5058

Dr. Emerman's Lab studies the molecular and evolutionary basis for the replication of HIV and related viruses, with an emphasis on the interaction of these viruses with their host cells. Our goal is to understand what determines resistance or vulnerability to current, past and potential viral diseases.

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Glenda Gray , MBBCH, FCPAED (SA), DSc (Honoris Causa)

Email: ggray@fredhutch.org

Phone: +27 21 938 0653

Professor Glenda Gray is both a pediatrician and a well-regarded scientist in the field of HIV prevention, specifically HIV vaccines and prevention of mother to child transmission. She is currently studying HIV-related malignancies but is very passionate about finding a vaccine for HIV, more specifically one that can control HIV. While in South Africa Professor Gray has been involved in the development of two HIV vaccines, both currently in clinical trials and hopes in the future she can help to optimize the vaccines. She holds many positions, one being the President and CEO of the Medical Research Council of South Africa. Among many awards and honors received, Professor Gray has been awarded the Nelson Mandel Health and Human Rights Award for her work in the field of mother to child transmission of HIV-1. Professor Gray is very passionate about developing the next generation of scientists in South Africa.

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Stephen Hawes , PhD

Email: hawes@u.washington.edu

Phone: (206) 616-9744

Dr. Hawes's primary interests are in human papillomavirus (HPV) and human immunodeficiency virus (HIV). His current research is conducted in Seattle and Senegal, West Africa and concerns the role of HIV, HPV and other sexually transmitted infections in the natural history of cervical neoplasia and cancer, as well as the study of biomarkers for various cancers including cancer of the cervix, anus, lung, breast, and skin. He is also interested in Alzheimer's disease.

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Rodney Ho , PhD

Email: Rodneyho@u.washington.edu

Phone: (206) 543-3796

Dr. Ho's research involves drug targeting and translational medicine. He has developed nanomedicine and device-enabled technologies that make anti-infective agents such as HIV, pain and cancer medications more effective and safe.

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Sarah Holte , PhD

Email: sholte@fredhutch.org

Phone: (206) 667-6975

Dr. Holte's general work is focused in mathematical and statistical modeling of time-varying biological processes. Her current interests lie in differential and difference equations to model the biology of HIV and the immune system.

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Hans-Peter Kiem , MD, PhD

Email: hkiem@fredhutch.org

Phone: (206) 667-4425

Dr. Kiem is experienced in pre-clinical and clinical studies involving stem cell biology including hematopoietic stem cell transplantation, gene therapy, and, more recently, induced pluripotent stem cells. As the Director of the preclinical and clinical vector program, Dr. Kiem is an expert in the generation and production of most viral and nonviral gene transfer techniques. His group has developed many different retroviral vectors and developed optimized lentivirus-mediated gene transfer conditions for hematopoietic stem cells. Dr. Kiem's research focus has been the study of stem cell biology and cell engineering with applications involving genetic and infectious diseases, such as HIV, and cancer, in particular glioblastoma. He also has extensive experience in studying stem cell biology and his pioneering work in gene transfer in large animal models, including the nonhuman primate model of AIDS, has led to several successful gene and stem cell therapy trials. Dr. Kiem also has significant knowledge in induced pluripotent stem cells (iPSCs), especially using nonhuman primate iPSCs, which hold a promising potential for improving safety in model human applications for the treatment blood stem cell and bone marrow related diseases.

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Shuying (Sue) Li , PhD

Email: sli@fredhutch.org

Phone: (206) 667-7066

Dr. Li is a senior scientist, whose research interests include development of genetic statistical methodologies, including phylogenetic tree reconstruction from genetic sequences, association of genetic markers with diseases, prediction of human leukocyte antigen (HLA) alleles from other polymorphisms such as single-nucleotide polymorphisms (SNPs), host genetics association with human immunity, especially immune-related diseases such as HIV infection and progression.

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Julie McElrath , MD, PhD

Email: jmcelrat@fredhutch.org

Phone: (206) 667-6704

Dr. McElrath's lab investigates how components of T-cell immunity elicited early in HIV-1 infection contribute to control of HIV-1 disease, what the influence of antiretroviral therapy is, whether T-cell immune responses are involved in resistance to HIV-1 infection in high-risk persons, how antigen-specific mucosal T cells protect against HIV-1 exposure, and what elements of immunity correlate with protection against HIV-1 infection by vaccine.

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James (Jim) Mullins , PhD

Email: jmullins@u.washington.edu

Phone: (206) 732-6163

Dr. Mullins's lab uses the techniques of molecular, computational and virus biology to provide basic insights into the HIV-human host relationship in an effort to assist the fight to stop the AIDS pandemic. His team uses a variety of techniques to understand the implications of HIV's extraordinary genetic diversity for the pathogenesis of AIDS, with the intention of applying this information to the development of more effective therapies and vaccines. These techniques include virology; and molecular biological and statistical analysis of nucleotide sequences.

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Warren Phipps , MD, MPH

Email: wtphipps@fhcrc.org

Dr. Phipps' research focuses on human herpesvirus-8 (HHV-8) virology and the pathogenesis of Kaposi sarcoma (KS), the most common HIV-associated malignancy worldwide. Specific areas of investigation include factors associated with KS presentation and treatment outcomes, as well as host and viral gene expression in KS tumors. Dr. Phipps serves as the Medical Director of the Uganda Cancer Institute / Hutchinson Center Cancer Alliance and oversees the program's research activities on infection-related cancers in Kampala, Uganda.

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Stephen Polyak , PhD

Email: polyak@uw.edu

Phone: 206-897-5224

Dr. Polyak's research focuses on the interactions between cells and viruses, with emphasis on hepatitis C virus (HCV) and HIV. One focus of his molecular virology and cell biology laboratory involves characterizing innate antiviral and inflammatory responses to virus infection. He also has a program focusing on how natural products combat chronic inflammation. Current efforts are focused on the liver protective natural product silymarin, generically known as milk thistle extract, on hepatic inflammation. Another project focuses on how natural products like silymarin reduce chronic immune activation associated with HIV infection. Research on the synthetic antiviral compound known as Arbidol (a.k.a. Umifenovir) has revealed that the drug is a broad spectrum antiviral compound, which inhibits infection of cells by many viruses, including HCV, Kaposi's sarcoma-associated herpesvirus (KSHV), certain Arenaviruses, and Ebola virus.

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Martin Prlic , PhD

Email: mprlic@fredhutch.org

Phone: 206-667-2216

The connecting theme throughout Dr. Prlic's research career has been his interest in lymphocyte differentiation. This started initially at the University of Salzburg, Austria, followed by his Ph.D. training at the University of Minnesota in the laboratory of Dr. Stephen Jameson. As a postdoctoral fellow at the University of Washington, he had the opportunity to establish his own T cell and NK cell research projects in the laboratory of Dr. Michael Bevan with a focus on T cell and NK cell responses in the context of infectious diseases. When Dr. Prlic started his own laboratory at the Fred Hutchinson Cancer Research Center in 2011, he continued his T cell work in the context of vaccination and infectious diseases. Through a close collaboration with Dr. Raphael Gottardo (FHCRC) his lab has started to examine human T cell subsets from blood and mucosal tissues using different single-cell gene expression analysis strategies. Dr. Prlic's overall goal is to understand how T cell fate and function are controlled in healthy and inflamed tissues and following infection with HIV to identify how these responses can be manipulated for therapeutic purposes.

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