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q=Lung

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Adam Alessio , PhD

Email: aalessio@uw.edu

Phone: (206) 543-2419

Dr. Alessio works with CT and PET cardiac perfusion imaging, protocol optimization for PET and CT, and tomographic image reconstruction problems with a particular interest in statistical issues regarding data analysis, organization, and reconstruction.

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David Au , MD, MS

Email: dau@uw.edu

Phone: (206) 764-2430

Dr. Au's research focuses on improving the quality and delivery of care for patients with chronic lung diseases, in particular, he is interested in primary pulmonary manifestations of tobacco smoke; COPD and lung cancer. His primary research focuses is on identifying and intervening upon potential gaps in the quality of care for patients with lung cancer and COPD. These gaps include a focus on the quality of end-of-life communication and care, delivery of high quality palliative care, heterogeneity in care, and whether health care delivery is concordant with best available evidence.

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Christina Baik , MD, MPH

Email: cbaik@fredhutch.org

Phone: (206) 288-7557

Dr. Baik's clinical interests are in lung, head and neck cancers. She is particularly interested in the development of molecular targeted therapies in lung cancer. Her research interests include: Targeted therapy in non-small cell lung cancer, immunotherapy, chemoprevention and identification of risk factors in non-small cell lung cancer particularly in never smokers, and the role of estrogen pathway in non-small cell lung cancers.

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Geoffrey Baird , MD, PhD

Email: gbaird@uw.edu

Phone: (206)744-9787

Dr. Baird's clinical interests include laboratory test utilization, molecular diagnostics, proteomics and immunohistochemistry. His group has developed a new proteomic technology for biomarker discovery in a range of diseases such as malignancies, cardiovascular disorders, and inflammatory conditions. One application of their technology is to discover protein expression changes associated with non-small cell lung cancer that have implications for diagnosis and treatment.

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Kevin Barry , PhD

Email: kbarry@fredhutch.org

Phone: (206) 667-7811

Dr. Barry aims to determine how innate immune cells recognize cancer and regulate immune responses. He previously identified a novel set of immune cells that regulate immune responses that protect patients from melanoma. The number of these cells in a patient’s tumor can identify those patients who will benefit the most from immunotherapy. Dr. Barry and his team are learning more about the signals that control this set of innate immune cells in cancer. His goal is to generate novel therapies to increase cancer-killing immune responses and save lives from cancer.

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Alice Berger , PhD

Email: ahberger@fredhutch.org

Phone: (206) 667-6281

The goal of the Berger laboratory is to enable precision medicine by systematically uncovering the molecular alterations in cancer, determining the function of these variant alleles, and understanding how these alleles modulate response to targeted or immune-based therapies. Although many of the genes involved in cancer have now been identified, a major challenge is discovering which specific alleles of these genes are involved and how these alleles modulate therapeutic response. We combine functional genomics, computational biology, biochemistry, and genetics to understand the mechanism of somatic cancer variants. Our goal is to identify drug targets and biomarkers and to translate this knowledge into clinical benefit for patients.

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Slobodan Beronja , PhD

Email: beronja@fredhutch.org

Phone: (206) 667-7609

Dr. Beronja's group studies molecular and cellular mechanisms essential for tissue growth during development and the formation of tumors. His goal is to identifying genes and gene pathways that can be used as targets in cancer therapy.

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Parveen Bhatti , PhD

Email: pbhatti@fredhutch.org

Phone: (206) 667-7803

Dr. Bhatti's research focus is on occupational and environmental epidemiology of cancer with a focus in biomarkers of exposure, susceptibility and disease; particularly genetic susceptibility to cancer following low dose exposure to occupational or medical ionizing radiation.

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Jesse Bloom , PhD

Email: jbloom@fredhutch.org

Phone: (206) 667-3622

Dr. Bloom studies the molecular evolution of proteins and viruses. Rapid evolution is a defining feature of many of the most medically problematic viral diseases, including influenza. Although this rapid evolution is usually bad from the perspective of public health, it offers a unique vantage from which to study a range of important questions in biology. His group takes an evolutionary perspective as we use a combination of experimental and computational techniques to study questions in virology, immunology, and protein biochemistry.

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Lynn Bonham , PhD

Email: lbonham@seattlecca.org

Phone: (206)288-2022

Dr. Bonham directs and manages Cellular Therapeutics at SCCA, which processes cells from peripheral blood, bone marrow and cord blood for standard transplantations and clinical trials for cancer treatment.

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Stephen Bowen , PhD

Email: srbowen@uw.edu

Phone: (206) 598-1128

Dr. Bowen's research focuses on quantitative molecular imaging of cancer and normal tissue for personalized radiation therapy. Specifically he is interested in machine learning of respiratory patterns for personalized motion management strategies during image acquisition, radiotherapy planning, and radiotherapy delivery; dose painting based on respiratory-gated FDG PET in NSCLC; and functional avoidance planning of both MAA and DTPA SPECT-defined lung regions in NSCLC and SC SPECT-defined liver regions in HCC.

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Ivana Bozic , PhD

Email: ibozic@uw.edu

Phone: (206) 543-5077

Dr. Bozic studies the evolution of cancer and its resistance to treatment through mathematical and computational modeling. Her interests lie in both theoretical aspects of these models and their application. On the theoretical side, Bozic studies stochastic processes, especially multi-type branching processes, and their finite time characteristics. Dr. Bozic collaborates extensively with experimental and clinical researchers to integrate modeling with clinical data, providing insight into the natural history of cancer in vivo.

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Roger Brent , PhD

Email: rbrent@fredhutch.org

Phone: (206) 667-1482

Dr. Brent studies the quantitative operation of the systems that living cells use to sense, represent, transmit, and act upon information to make decisions that determine their future fates. He specifically studies prototypic cell signaling systems in budding yeast and the pheromone response system; he has extended similar work to systems operating in single cells of tissues in a metazoan, Caenorhabditis elegans.

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James (Jim) Brinkley , MD, PhD

Email: brinkley@u.washington.edu

Phone: (206) 543-3954

Dr. Brinkley's primary research interest is biomedical informatics - the representation, management, sharing, visualization and utilization of neuroscience data and knowledge. He is the founder of the field of Structural Informatics, which has as its goal the development of methods for representing the structure of the body at multiple levels of detail, as for using these methods for organizing and integrating biomedical information. His aim is to find ways to represent the structure or the body in computer-readable form, and find ways to associate these representations with the myriad biomedical data that are available. His goal is to provide a structural information framework for integrating a huge variety of big and small biomedical data. Dr. Brinkley's projects have included anatomy education, brain mapping through the national Human Brain Project, cardiovascular data integration, clinical trials data integration through the national Clinical translational Science Awards, radiological image annotation and integration through the RadLex project, and craniofacial malformations data integration through the national FaceBase consortium. He is also interested in developing web-accessible computer applications utilizing these representations to solve practical problems in clinical medicine, research and education.

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Mac Cheever , MD

Email: mcheever@fredhutch.org

Phone: (206) 667-4141

Dr. Cheever's specialty is in the areas of medical oncology, immunotherapy and solid tumor research. His current research interests are in conducting cancer clinical trials to develop and test new immunotherapies. He also interested on developing the principles of T cell therapy, cancer antigen discovery and development of cancer vaccines, especially for breast cancer.

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Chu Chen , PhD, NRCC, DABCC

Email: cchen@fredhutch.org

Phone: (206) 667-6644

Dr. Chen's research interests include the identification of 1) diagnostic and prognostic markers to aid personalized management of head and neck cancer based on gene expression profiles, loss of heterozygosity, DNA copy number, and tissue microarray data.; and 2) determinants for the susceptibility to and survival from cancers of the head and neck, lung, endometrium, breast, prostate and testes through investigations into lifestyle factors, endogenous and environmental exposures, and genetic and epigenetic influences.

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Guang-Shing Cheng , MD

Email: cheng3@uw.edu

Phone: (206) 667-7074

Dr. Cheng specializes in pulmonary complications from bone marrow transplants and malignancies, unusual pulmonary infections. Her research focuses on improving outcomes for stem cell transplant patients with pulmonary complication and on advancing diagnostic strategies for early detection of lung cancer.

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David Chhieng , MD, MBA, MSHI, MSEM, MA (HON)

Email: dchhieng@uw.edu

Phone: (206) 598-3315

Dr. Chhieng is director of Anatomic Pathology and a UW profession of pathology. He is surgical pathologist, with expertise in cytopathology, especially in performing and interpreting fine needle aspiration biopsy (FNA). Dr. Chhieng is board certified in Anatomic and Clinical Pathology, Cytopathology, and Clinical Informatics.

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Bruce Clurman , MD, PhD

Email: bclurman@fredhutch.org

Phone: (206) 667-4524

Dr. Clurman's studies the pathways that regulate cell growth and division in order to understand the molecular mechanisms that drive tumorigenesis and to develop new cancer therapies. His research focuses on two general areas: cellular regulation by the ubiquitin-proteasome system, and control of cell division by cyclin-dependent kinases (CDKs).His clinical practice is focused on hematopoietic stem cell transplantation.

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Keith Eaton , MD, PhD

Email: kdeaton@u.washington.edu

Phone: (206) 288-7485

Dr. Eaton applies expert research knowledge to treating patients with lung cancer. His clinical expertise is in the areas of lung cancer, head and neck cancer, thyroid cancer, and cancer of unknown primary. His research interests include Immunotherapy and Targeted Therapies.

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