7 Search Results

q=Structural%20Biology

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Niels Andersen , PhD

Email: andersen@chem.washington.edu

Phone: (206) 543-7099

Dr. Anderson's research team focuses on both the fundamental thermodynamics and structural features associated with biorecognition phenomena and practical applications in drug and protein design. The primary biophysical tools employed are spectroscopic: NMR determinations of polypeptide structure and dynamics, IR- and fluorescence-monitored T-jump kinetics for folding pathways, CD studies of the melting of secondary and tertiary structure. His drug design efforts are supported by NMR structural data for protein hormones and enzymes for key steps required for the viability of bacteria.

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Phil Bradley , PhD

Email: pbradley@fredhutch.org

Phone: (206) 667-7041

Dr. Bradley's research is focused on developing predictive models of molecular recognition using high-resolution structural modeling. His group is currently working to predict the specificity of protein-DNA and protein-peptide interactions. They develop and apply new algorithms for molecular modeling within the framework of the Rosetta software package, a set of tools for the prediction and design of protein structures and interactions.

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Zhijun Duan , PhD

Email: zjduan@uw.edu

Phone: (206) 543-3363

Dr. Duan's research is focused on the relationship between the form and function of human genomes during development and tumorigenesis. One of the striking features of the eukaryotic nucleus is that chromosomes adopt preferred conformations that vary across different tissues and developmental stages.

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Steven Hahn , PhD

Email: shahn@fredhutch.org

Phone: (206) 667-5261

Dr. Hahn's Laboratory focus is the mechanism and regulation of transcription. In eukaryotes, RNA polymerases are components of large protein machines that integrate regulatory signals and position polymerase at gene regulatory regions. Most subunits of the transcription machinery are essential for viability, and regulation of transcription is one of the key steps controlling cell identity, growth, development and stress response. Misregulation of transcription is a major cause of human disease. Research in his laboratory aims to decipher key mechanisms used by the transcription machinery and by regulatory factors that are fundamental to the regulation of transcription.

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Laura Riolobos , PhD

Email: lriolobo@uw.edu

Phone: 206-221-6454

Dr. Riolobos received her PhD in Molecular Biology from Universidad Autonoma of Madrid in 2006. During her PhD she studied the nuclear transport of Parvovirus structural proteins and the capsid assembly intermediates. After graduation, she worked as a Research scientist at Protein Alternatives in Madrid where she optimized the Phage Display technology to obtain specific antibodies against colorectal cancer biomarkers. In 2010, she joined the University of Washington as a Senior Fellow in the Hematolgoy Department, her project aimed to obtain “Universal” Stem Cells that would not be recognized as allogeneic by knocking-down the B2M and HLA-I genes. Currently, Dr. Riolobos is working with the CVI on the development and characterization of vaccines for lung cancers.

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Barry Stoddard , PhD

Email: bstoddar@fredhutch.org

Phone: (206) 667-4031

Dr. Stoddard's lab focuses on to understanding the structure/function relationships of several interesting biological systems at the atomic level. The tools employed by his team are X-ray crystallography, computer modelling, and genetic manipulation of the molecules of interest

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Roland Strong , PhD

Email: rstrong@fredhutch.org

Phone: (206) 667-5587

Dr. Strong's lab research focuses on structural molecular immunology and vaccinology by using biophysical approaches to study proteins and interactions mediating or modulating adaptive and innate immune responses.

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