Mark Binder PhD

physiology , Markov models , multivariate analysis , clustering , stochastic process , modeling , information theory , membranes , morphology , signaling pathways , imaging , single-cell assays , education , University of Washington


Dr. Binder's lab is presently investigating the dendritic mechanisms affecting the transfer of synaptic current to the soma of hypoglossal motoneurons recorded in rat brainstem slices. His team studies the voltage-dependance of the synaptic currents, what types of voltage-gated conductances on the dendrites affect the transfer of current to the soma and how concurrently-activated synaptic currents interact. They also use fluorescent imaging to determine the spatial distribution of the dendritic sodium, calcium, and mixed-cation channels. Binder's experimental projects are complemented by computer simulations using compartmental models of motoneurons with different types and distributions of dendritic conductances to help interpret the experimental data.


University of Washington Physiology and Biophysics Professor