Linda Breeden PhD



yeast molecular genetics , genomics/genetics , bio/chemistry , physiology , cell cycle , signaling pathways , flow/FACS

Bio


Dr. Breeden's research is focused on understanding how the commitment to the mitotic cell cycle is regulated in response to environmental and internal cues. The critical transitions in the eukaryotic cell cycle are controlled by cyclin-dependent kinases (CDKs). In budding yeast, as in all higher eukaryotes, the decision to commit to another division cycle occurs in G1. Nine cyclins have been identified that bind and activate a single CDK, and three of these cyclins (Cln1,2 and 3) play critical roles in modulating the decision to enter the cell cycle. Her lab's long term goal has been to understand how the commitment to the mitotic cell cycle is regulated in response to environmental and internal cues. Most of this work has been done with rapidly growing cells and with cells subjected to DNA damage.

Institution


Fred Hutch Basic Sciences Professor
University of Washington School of Medicine Genetics Affiliate Associate Professor