Gerald Smith PhD

chromosome dynamics , genomics/genetics , recombination , DNA damage/repair , chromatin structure (histones, centromere, telomere)


Dr. Smith's research goals are to elucidate how recombination and DSB repair are accomplished and how they are regulated to occur at the proper place and time. His lab work is focused on meiotic recombination in the fission yeast Schizosaccharomyces pombe and on the major (RecBCD) pathway of recombination in the bacterium Escherichia coli. In both organisms he approaches this problem genetically, by analyzing mutants altered in the process, and biochemically, by studying the enzymes and special DNA sites (hotspots) that promote recombination and repair. These approaches are greatly facilitated by the advanced genetics and biochemistry of these microorganisms.


Fred Hutch Basic Sciences Professor
University of Washington School of Medicine Genome Sciences and Pathology Affiliate Professor