The research in Dr. Ning Zheng's lab focuses on a superfamily of multi-component protein complexes, known as cullin-RING ubiquitin ligases as well as the emerging family of ubiquitin-specific proteases. By controlling protein turnover, these cellular machines regulate diverse biological processes, such as cell cycle progression, signal transduction, transcription, DNA repair, and metabolism. Dysregulation of these complexes has been associated with multiple human disorders including cancer, neurological disease, and viral infection. He utilizes protein complex X-ray crystallography in his research to determine the atomic 3-D structures of the protein machines they are interested in and identify novel therapeutic targets for developing anti-cancer treatments.


University of Washington School of Medicine Pharmacology Professor